2. Neuronal Signaling Immunology/Inflammation GPCR/G Protein Membrane Transporter/Ion Channel Metabolic Enzyme/Protease
  3. Histamine Receptor Potassium Channel Endogenous Metabolite
  4. Dimethindene

Dimethindene is a potent, selective histamine H1 antagonist. Dimethindene impairs cutaneous wound healing (WH). Dimethindene can block K+ currents.

The free form of the compound is prone to instability, it is advisable to consider the stable salt form (Dimethindene maleate) that retains the same biological activity.

For research use only. We do not sell to patients.

Dimethindene Chemical Structure

Dimethindene Chemical Structure

CAS No. : 5636-83-9

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Other Forms of Dimethindene:

Dimethindene Related Antibodies

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Description

Dimethindene is a potent, selective histamine H1 antagonist. Dimethindene impairs cutaneous wound healing (WH). Dimethindene can block K+ currents[1][2].

In Vitro

Dimethindene (5-500 μM; follicle-enclosed Xenopus oocytes) decreases Cromakalim cromakalim-induced K+ currents with an IC50 value of 29.5 μM[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Dimethindene Related Antibodies
In Vivo

Dimethindene (0.25 mg; i.p.; once; C57BL/6 mice with skin WH) impaires cutaneous wound healing (WH) and delays skin wound closure[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice with skin WH[1]
Dosage: 0.25 mg
Administration: intraperitoneal injection; once
Result: Delayed skin wound closure as compared to vehicle treated mice.
Molecular Weight

292.42

Formula

C20H24N2
CAS No.
SMILES

CC(C1=C(CCN(C)C)CC2=C1C=CC=C2)C3=NC=CC=C3
Structure Classification
Initial Source
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
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References
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Dimethindene Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dimethindene5636-83-9Histamine ReceptorPotassium ChannelEndogenous MetaboliteKcsAcutaneous wound healingK+ currentsfollicle-enclosed Xenopus oocytesInhibitorinhibitorinhibit

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