2. Neuronal Signaling Immunology/Inflammation GPCR/G Protein Metabolic Enzyme/Protease
  3. Histamine Receptor Endogenous Metabolite
  4. Dimethindene maleate

Dimethindene maleate is a selective histamine H1 antagonist with antihistamine effects. Dimethindene maleate can be used for the research of hypersensitivity reactions.

For research use only. We do not sell to patients.

Dimethindene maleate Chemical Structure

Dimethindene maleate Chemical Structure

CAS No. : 3614-69-5

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Based on 1 publication(s) in Google Scholar

Other Forms of Dimethindene maleate:

Dimethindene maleate Related Antibodies

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Description

Dimethindene maleate is a selective histamine H1 antagonist with antihistamine effects. Dimethindene maleate can be used for the research of hypersensitivity reactions[1][2][3].

IC50 & Target

IC50: 29.5 μM (cromakalim-induced K＋ currents), 49 μM (Y-26763-induced K＋ currents)[2]
In Vitro

Dimethindene maleate (1-1000 μM) suppresses the cromakalim-induced/glibenclamide-sensitive K＋ currents in a concentration-dependent and reversible manner with an IC50 value of 29.5 μM[2].
Dimethindene maleate (1-1000 μM) inhibits Y-26763-induced glibenclamide-sensitive K＋ currents with an IC50 value of 49 μM[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Dimethindene maleate Related Antibodies
In Vivo

Dimethindene maleate (0.25 mg; i.p. once) affects wound healing in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice with wound healing[1]
Dosage: 0.25 mg
Administration: Intraperitoneal injection; 0.25 mg once
Result: Significantly delayed skin wound and only showed wound closure impairment in the initial phase wound healing.
Molecular Weight

408.49

Formula

C24H28N2O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC(C1=C(CCN(C)C)CC2=C1C=CC=C2)C3=NC=CC=C3.O=C(O)/C=C\C(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (306.01 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4480 mL 12.2402 mL 24.4804 mL
5 mM 0.4896 mL 2.4480 mL 4.8961 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4480 mL 12.2402 mL 24.4804 mL 61.2010 mL
5 mM 0.4896 mL 2.4480 mL 4.8961 mL 12.2402 mL
10 mM 0.2448 mL 1.2240 mL 2.4480 mL 6.1201 mL
15 mM 0.1632 mL 0.8160 mL 1.6320 mL 4.0801 mL
20 mM 0.1224 mL 0.6120 mL 1.2240 mL 3.0601 mL
25 mM 0.0979 mL 0.4896 mL 0.9792 mL 2.4480 mL
30 mM 0.0816 mL 0.4080 mL 0.8160 mL 2.0400 mL
40 mM 0.0612 mL 0.3060 mL 0.6120 mL 1.5300 mL
50 mM 0.0490 mL 0.2448 mL 0.4896 mL 1.2240 mL
60 mM 0.0408 mL 0.2040 mL 0.4080 mL 1.0200 mL
80 mM 0.0306 mL 0.1530 mL 0.3060 mL 0.7650 mL
100 mM 0.0245 mL 0.1224 mL 0.2448 mL 0.6120 mL
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Dimethindene maleate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dimethindene3614-69-5Histamine ReceptorEndogenous Metabolitexenopus oocytepromethazinewound healingglibenclamidecromakalimmiceInhibitorinhibitorinhibit

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