Dios-Arg diTFA 

Dios-Arg diTFA, a cationic lipid with an arginine-bearing headgroup, shows obvious double bond proton signals at around 5.2-5.3 ppm. Dios-Arg diTFA is used, coupled to DOPE, to bind siRNA and plasmid to for cationic LNPs for intracellular transport^[1][2].

Dios-Arg shows high cytotoxicity (IC₅₀ = 83.5 µg/mL in H1299; and IC₅₀ = 74.1 µg/mL in HeLa), which may be due to the inhibition effect of diosgenin on HMG-CoA reductase, a rate-limiting enzyme involved in cholesterol biosynthesis^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

912.01

C₄₃H₆₇F₆N₅O₉

1807353-31-6

[H][C@]1(O[C@@]2(OC[C@H](C)CC2)[C@H]3C)C[C@@]4([H])[C@]5([H])CC=C6C[C@@H](OC(CCCCCNC([C@@H](N)CCCNC(N)=N)=O)=O)CC[C@]6(C)[C@@]5([H])CC[C@]4(C)[C@]13[H].O=C(O)C(F)(F)F.O=C(O)C(F)(F)F

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Ruilong Sheng, et al. Cationic Nanoparticles Assembled from Natural-Based Steroid Lipid for Improved Intracellular Transport of siRNA and pDNA. Nanomaterials (Basel). 2016 Apr 13;6(4):69.  [Content Brief]

  [2]. Ruilong Sheng, et al. Skeleton-Controlled pDNA Delivery of Renewable Steroid-Based Cationic Lipids, the Endocytosis Pathway Analysis and Intracellular Localization. Int J Mol Sci. 2018 Jan 26;19(2):369.  [Content Brief]