DIPPA hydrochloride

Name: DIPPA hydrochloride
Brand: MedChemExpress
SKU: HY-101223
Rating: 4.5 (1 reviews)

Cat. No.: HY-101223 Purity: 99.7%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

DIPPA (hydrochloride) is an irreversible, long-lasting, selective and high affinity κ-opioid receptor antagonist. DIPPA (hydrochloride) can be used for the research of anxiety and antidepressant.

For research use only. We do not sell to patients.

DIPPA hydrochloride Chemical Structure

CAS No. : 155512-52-0

Size	Price	Stock	Quantity
5 mg	USD 316	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 506	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Opioid Receptor Isoform Specific Products:

View All Isoforms

μ Opioid Receptor/MOR κ Opioid Receptor/KOR δ Opioid Receptor/DOR NOP Receptor/ORL1

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

κ Opioid Receptor/KOR

In Vivo

DIPPA (2.5 and 5 mg/kg; s.c.) hydrochloride decreases the latency to feed in Wistar Kyoto rats, but treatment did not alter approach latencies in SD rats^[2].
DIPPA (1 and 5 mg/kg; s.c.) hydrochloride high dose increases immobility in SD rats compared to the saline-treated strain control group^[2].
DIPPA (5 mg/kg) hydrochloride decreases consumption in SD rats compared to the 5 mg/kg group of Wistar Kyoto rats. DIPPA hydrochloride significantly decreases burying time in both strains. DIPPA (5 mg/kg) hydrochloride decreases burying in both strains compared to the within strain control groups. DIPPA hydrochloride tends to decrease consumption in SD rats in the home cage but significantly increases feeding in the novel cage where potential anxiolytic-like effects of DIPPA hydrochloride may oppose the hypophagic effects of the compound^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Wistar Kyoto rats and SD rats (250–300 g)^[2]
Dosage:	2.5 and 5 mg/kg
Administration:	S.c.
Result:	Decreased the latency to feed in Wistar Kyoto rats, but treatment did not alter approach latencies in SD rats.

Animal Model:	Wistar Kyoto rats and SD rats (250–300 g)^[2]
Dosage:	1 and 5 mg/kg
Administration:	S.c.
Result:	High dose increased immobility in SD rats compared to the saline-treated strain control group.

Molecular Weight

484.87

Formula

C₂₂H₂₄Cl₃N₃OS

CAS No.

155512-52-0

Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(N([C@@H](C1=CC=CC(N=C=S)=C1)CN2CCCC2)C)CC3=CC=C(Cl)C(Cl)=C3.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 24 mg/mL (49.50 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.0624 mL	10.3120 mL	20.6241 mL
5 mM	0.4125 mL	2.0624 mL	4.1248 mL
10 mM	0.2062 mL	1.0312 mL	2.0624 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.7%

Select Batch:

Data Sheet (276 KB) SDS (644 KB)

COA (250 KB) Elemental Analysis Report (109 KB)

Handling Instructions (2659 KB)

References

[1]. Jones DC, et al. Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis. Biochem Pharmacol. 2010;80(10):1478-1486. [Content Brief]

[2]. Carr GV, et al. Comparison of the kappa-opioid receptor antagonist DIPPA in tests of anxiety-like behavior between Wistar Kyoto and Sprague Dawley rats. Psychopharmacology (Berl). 2010;210(2):295-302. [Content Brief]

[3]. Costello GF, et al. 2-(3,4-Dichlorophenyl)-N-methyl-N-[2-(1-pyrrolidinyl)-1-substituted- ethyl]-acetamides: the use of conformational analysis in the development of a novel series of potent opioid kappa agonists. J Med Chem. 1991;34(1):181-189. [Content Brief]

[4]. Chang AC, et al. kappa Opioid receptor selective affinity labels: electrophilic benzeneacetamides as kappa-selective opioid antagonists. J Med Chem. 1994;37(26):4490-4498. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.0624 mL	10.3120 mL	20.6241 mL	51.5602 mL
	5 mM	0.4125 mL	2.0624 mL	4.1248 mL	10.3120 mL
	10 mM	0.2062 mL	1.0312 mL	2.0624 mL	5.1560 mL
	15 mM	0.1375 mL	0.6875 mL	1.3749 mL	3.4373 mL
	20 mM	0.1031 mL	0.5156 mL	1.0312 mL	2.5780 mL
	25 mM	0.0825 mL	0.4125 mL	0.8250 mL	2.0624 mL
	30 mM	0.0687 mL	0.3437 mL	0.6875 mL	1.7187 mL
	40 mM	0.0516 mL	0.2578 mL	0.5156 mL	1.2890 mL