1. Cell Cycle/DNA Damage
  2. DNA/RNA Synthesis
  3. Ditercalinium chloride

Ditercalinium chloride  (Synonyms: NSC335153)

Cat. No.: HY-19587 Purity: 96.12%
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Ditercalinium chloride is an anticancer agent. Ditercalinium chloride inhibits human DNA polymerase gamma activity. Ditercalinium chloride can deplete mitochondrial DNA in both mouse and human cells. Ditercalinium chloride is a potential ligand against the COMMD10-AP3S1 fusion protein.

For research use only. We do not sell to patients.

Ditercalinium chloride Chemical Structure

Ditercalinium chloride Chemical Structure

CAS No. : 74517-42-3

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Based on 1 publication(s) in Google Scholar

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Description

Ditercalinium chloride is an anticancer agent. Ditercalinium chloride inhibits human DNA polymerase gamma activity. Ditercalinium chloride can deplete mitochondrial DNA in both mouse and human cells. Ditercalinium chloride is a potential ligand against the COMMD10-AP3S1 fusion protein[1][2].

Cellular Effect
Cell Line Type Value Description References
L1210 ED50
0.19 μM
Compound: Ditercalinium
Dose required to inhibit growth of L1210 cells after 24-h exposure to the compound
Dose required to inhibit growth of L1210 cells after 24-h exposure to the compound
[PMID: 1732535]
Molecular Weight

789.83

Formula

C46H50Cl2N6O2

CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

COC1=CC2=C(NC3=C2C4=C[N+](CCN5CCC(C6CCN(CC[N+]7=CC=C8C=CC(NC9=C%10C=C(OC)C=C9)=C%10C8=C7)CC6)CC5)=CC=C4C=C3)C=C1.[Cl-].[Cl-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 2 mg/mL (2.53 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2661 mL 6.3305 mL 12.6610 mL
5 mM --- --- ---
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 96.12%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.2661 mL 6.3305 mL 12.6610 mL 31.6524 mL
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Ditercalinium chloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Ditercalinium chloride
Cat. No.:
HY-19587
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