2. Cell Cycle/DNA Damage TGF-beta/Smad Stem Cell/Wnt Cytoskeleton
  3. ROCK
  4. DJ4

DJ4 is a ATP-competitive inhibitor of ROCK1/2 (IC50 values:5 and 50 nM) and MRCKα/β (IC50 values:10 and 100 nM). DJ4 blocks stress fiber formation and induces cell apoptosis. DJ4 can be used for study of cancer.

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DJ4 Chemical Structure

DJ4 Chemical Structure

CAS No. : 1681020-24-5

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5 mg USD 162 In-stock
10 mg USD 260 In-stock
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Based on 1 publication(s) in Google Scholar

DJ4 Related Antibodies

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ROCK ROCK1 ROCK2

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Description

DJ4 is a ATP-competitive inhibitor of ROCK1/2 (IC50 values:5 and 50 nM) and MRCKα/β (IC50 values:10 and 100 nM). DJ4 blocks stress fiber formation and induces cell apoptosis. DJ4 can be used for study of cancer[1].

IC50 & Target

ROCK1

5 nM (IC50)

ROCK2

50 nM (IC50)

Molecular Weight

348.42

Formula

C19H16N4OS
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C1N/C(S/C1=C/C2=CNC3=C2C=CC=N3)=N\CCC4=CC=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (28.70 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8701 mL 14.3505 mL 28.7010 mL
5 mM 0.5740 mL 2.8701 mL 5.7402 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

V1

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Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8701 mL 14.3505 mL 28.7010 mL 71.7525 mL
5 mM 0.5740 mL 2.8701 mL 5.7402 mL 14.3505 mL
10 mM 0.2870 mL 1.4350 mL 2.8701 mL 7.1752 mL
15 mM 0.1913 mL 0.9567 mL 1.9134 mL 4.7835 mL
20 mM 0.1435 mL 0.7175 mL 1.4350 mL 3.5876 mL
25 mM 0.1148 mL 0.5740 mL 1.1480 mL 2.8701 mL
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DJ4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DJ41681020-24-5DJ 4DJ-4ROCKRho-associated protein kinaseRho-associated kinaseRho-kinaseROKstress fiberscancerInhibitorinhibitorinhibit

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