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DL-Penicillamine  (Synonyms: (±)-Penicillamine)

Cat. No.: HY-W017457 Purity: ≥98.0%
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DL-Penicillamine [(±)-Penicillamine] is a copper chelating agent. DL-Penicillamine has antidotal effects in thallotoxicosis rats when co-treated with Prussian blue (HY-106594A). DL-Penicillamine can cause pyridoxine deficiency and then induce optic axial neuritis. DL-Penicillamine can also depress primary immune response.

For research use only. We do not sell to patients.

DL-Penicillamine Chemical Structure

DL-Penicillamine Chemical Structure

CAS No. : 52-66-4

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
In-stock
Solution
10 mM * 1 mL in Water In-stock
Solid
5 mg In-stock
10 mg In-stock
25 mg In-stock
50 mg In-stock
100 mg In-stock
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500 mg   Get quote  

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Other Forms of DL-Penicillamine:

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Description

DL-Penicillamine [(±)-Penicillamine] is a copper chelating agent. DL-Penicillamine has antidotal effects in thallotoxicosis rats when co-treated with Prussian blue (HY-106594A). DL-Penicillamine can cause pyridoxine deficiency and then induce optic axial neuritis. DL-Penicillamine can also depress primary immune response[1][2][3].

In Vivo

DL-Penicillamine (25 mg/kg; i.p.; twice daily, for 5 days) has antidotal effects in thallotoxicosis rats when co-treated with Prussian blue (HY-106594A)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats, NIH strain (intoxicated by i.p. injection of 32 mg/kg thallium (I) acetate)[2]
Dosage: 25 mg/kg
Administration: i.p.; twice daily, for 5 days
Result: Decreased slightly the thallium content in blood, organs and brain.
Increased the probability survival when co-treated with Prussian blue (50 mg/kg; p.o.).
Molecular Weight

149.22

Formula

C5H11NO2S

CAS No.
Appearance

Solid

Color

Off-white to pale purple

SMILES

CC(C(N)C(O)=O)(S)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

H2O : 33.33 mg/mL (223.37 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.7017 mL 33.5087 mL 67.0174 mL
5 mM 1.3403 mL 6.7017 mL 13.4035 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 6.7017 mL 33.5087 mL 67.0174 mL 167.5435 mL
5 mM 1.3403 mL 6.7017 mL 13.4035 mL 33.5087 mL
10 mM 0.6702 mL 3.3509 mL 6.7017 mL 16.7543 mL
15 mM 0.4468 mL 2.2339 mL 4.4678 mL 11.1696 mL
20 mM 0.3351 mL 1.6754 mL 3.3509 mL 8.3772 mL
25 mM 0.2681 mL 1.3403 mL 2.6807 mL 6.7017 mL
30 mM 0.2234 mL 1.1170 mL 2.2339 mL 5.5848 mL
40 mM 0.1675 mL 0.8377 mL 1.6754 mL 4.1886 mL
50 mM 0.1340 mL 0.6702 mL 1.3403 mL 3.3509 mL
60 mM 0.1117 mL 0.5585 mL 1.1170 mL 2.7924 mL
80 mM 0.0838 mL 0.4189 mL 0.8377 mL 2.0943 mL
100 mM 0.0670 mL 0.3351 mL 0.6702 mL 1.6754 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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DL-Penicillamine Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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