2. GPCR/G Protein
  3. Guanylate Cyclase
  4. Dolcanatide

Dolcanatide is an orally active GC-C (guanylate cyclase-C) agonist. Dolcanatide shows laxative, anti-nociceptive and anti-inflammatory activity. Dolcanatide can be used in inflammatory bowel disease research.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Dolcanatide Chemical Structure

Dolcanatide Chemical Structure

CAS No. : 1092457-65-2

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1 mg USD 220 In-stock
5 mg USD 550 In-stock
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Based on 1 publication(s) in Google Scholar

Dolcanatide Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Dolcanatide is an orally active GC-C (guanylate cyclase-C) agonist. Dolcanatide shows laxative, anti-nociceptive and anti-inflammatory activity. Dolcanatide can be used in inflammatory bowel disease research[1][2].

In Vitro

Dolcanatide (0-10 μM; 30 min) activates GC-C receptors to stimulate cGMP synthesis in a dose-dependent manner in T84 cells[2].
Dolcanatide (1 μM; 16 h) suppresses lipopolysaccharide-induced paracellular permeability in Caco-2 and T84 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Dolcanatide Related Antibodies

Cell Viability Assay[2]

Cell Line: T84 cells
Concentration: 0-10 μM
Incubation Time: 30 min
Result: Showed EC50 value of 0.28 μM.
In Vivo

Dolcanatide (oral administration; 0.01 and 0.05 mg/kg; once) alleviates TNBS-induced rectal allodynia in rats[1].
Dolcanatide (oral administration; 0.01 and 0.05 mg/kg; once) alleviates stress-induced colorectal hypersensitivity (CRD) in rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: TNBS-induced rectal allodynia in rats[1]
Dosage: 0.01 and 0.05 mg/kg
Administration: Oral administration; 0.01 and 0.05 mg/kg; once
Result: Attenuated the TNBS-induced increase in the number of abdominal contractions (distending pressures up to 60 mmHg).
Animal Model: Stress-induced visceral hypersensitivity in Wistar rats[1]
Dosage: 0.01 and 0.05 mg/kg
Administration: Oral administration; 0.01 and 0.05 mg/kg; once
Result: Resulted in a significant reduction in the rate of PRS (partial restraint stress)-induced abdominal contractions with increasing CRD (colorectal distension) pressures.
Clinical Trial
Molecular Weight

1681.89

Formula

C65H104N18O26S4
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

{d-Asn}--Asp-Glu-Cys-Glu-Leu-Cys-Val-Asn-Val-Ala-Cys-Thr-Gly-Cys-{d-Leu} (Disulfide bridge: Cys4-Cys12; Cys7-Cys15)
Sequence Shortening

{d-Asn}-DECELCVNVACTGC-{d-Leu} (Disulfide bridge: Cys4-Cys12; Cys7-Cys15)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Stored under nitrogen, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (59.46 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.5946 mL 2.9728 mL 5.9457 mL
5 mM 0.1189 mL 0.5946 mL 1.1891 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C1

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.39%

COA (257 KB) RP-HPLC (111 KB) MS (225 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.5946 mL 2.9728 mL 5.9457 mL 14.8642 mL
5 mM 0.1189 mL 0.5946 mL 1.1891 mL 2.9728 mL
10 mM 0.0595 mL 0.2973 mL 0.5946 mL 1.4864 mL
15 mM 0.0396 mL 0.1982 mL 0.3964 mL 0.9909 mL
20 mM 0.0297 mL 0.1486 mL 0.2973 mL 0.7432 mL
25 mM 0.0238 mL 0.1189 mL 0.2378 mL 0.5946 mL
30 mM 0.0198 mL 0.0991 mL 0.1982 mL 0.4955 mL
40 mM 0.0149 mL 0.0743 mL 0.1486 mL 0.3716 mL
50 mM 0.0119 mL 0.0595 mL 0.1189 mL 0.2973 mL
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Dolcanatide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dolcanatide1092457-65-2Guanylate Cyclaseoral activitylaxativeanti-nociceptive activityanti-inflammatory activityinflammatory bowel diseaseCaco-2T84Inhibitorinhibitorinhibit

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