1. Epigenetics
  2. Histone Methyltransferase
  3. Dot1L-IN-9

Dot1L-IN-9 (Compound 12) is a DOT1L inhibitor (IC50: 125 nM). Dot1L-IN-9 reduces H3K79 dimethylation. Dot1L-IN-9 can be used for anti-leukemia research.

For research use only. We do not sell to patients.

Dot1L-IN-9 Chemical Structure

Dot1L-IN-9 Chemical Structure

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Description

Dot1L-IN-9 (Compound 12) is a DOT1L inhibitor (IC50: 125 nM). Dot1L-IN-9 reduces H3K79 dimethylation. Dot1L-IN-9 can be used for anti-leukemia research[1].

IC50 & Target[1]

DOT1L

125 nM (IC50)

Molecular Weight

534.65

Formula

C28H38N8O3

SMILES

NC1=C2N=CN(C2=NC=N1)[C@@H]3O[C@H](CN4CCC(CCC5=NC6=CC(C(C)(C)C)=CC=C6N5)CC4)[C@@H](O)[C@H]3O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Dot1L-IN-9
Cat. No.:
HY-168083
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