2. Antibody-drug Conjugate/ADC Related GPCR/G Protein Neuronal Signaling
  3. Radionuclide-Drug Conjugates (RDCs) Somatostatin Receptor
  4. DOTA-NOC

DOTA-NOC (DOTA-Nal3-octreotide) is a high-affinity ligand of somatostatin receptor subtypes 2, 3 and 5. DOTA-NOC can be used for labeling with various radiometals, and development of radiopeptide imaging.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

DOTA-NOC Chemical Structure

DOTA-NOC Chemical Structure

CAS No. : 619300-53-7

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DOTA-NOC Related Antibodies

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RDC Peptide RDC Antibody RDC Bifunctional Chelator RDC Linker Other

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SSTR1 SSTR2 SSTR3 SSTR5 SSTR4

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Description

DOTA-NOC (DOTA-Nal3-octreotide) is a high-affinity ligand of somatostatin receptor subtypes 2, 3 and 5. DOTA-NOC can be used for labeling with various radiometals, and development of radiopeptide imaging[1].

IC50 & Target

RDC Peptide

 

In Vitro

Affinity profiles (IC50(μM)) for human somatostatin receptor (SST) 1-5[1].

Compound hsst1 hsst2 hsst3 hsst4 hsst5
InIII-DOTA-NOC >10000 2.9 8 227 11.2
YIII-DOTA-NOC >10000 3.3 26 >10000 10.4

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DOTA-NOC Related Antibodies
Molecular Weight

1455.70

Formula

C69H94N14O17S2
CAS No.
Sequence

DOTA-{d-Phe}-Cys-{Nal}-{d-Trp}-Lys-Thr-Cys-Thr-ol (Disulfide bridge: Cys2-Cys7)
Sequence Shortening

DOTA-{d-Phe}-C-{Nal}-{d-Trp}-KTCT-ol (Disulfide bridge: Cys2-Cys7)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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DOTA-NOC Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DOTA-NOC619300-53-7DOTA-Nal3-octreotideRadionuclide-Drug Conjugates (RDCs)Somatostatin ReceptorSSTRsSSTRRadiometalradiopeptidePETInhibitorinhibitorinhibit

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