DOTAGA.(SA.FAPi)2 TFA

Cat. No.: HY-164364A Purity: 96.81%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

DOTAGA.(SA.FAPi)2 TFA is a potent dimeric fibroblast-activation protein inhibitor (FAPi). DOTAGA.(SA.FAPi)2 TFA has the potential for cancer diagnosis research.

For research use only. We do not sell to patients.

DOTAGA.(SA.FAPi)2 TFA Chemical Structure

Size	Price	Stock	Quantity
1 mg	USD 1550	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 3900	In-stock	Estimated Time of Arrival: December 31
10 mg		Get quote
50 mg		Get quote

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Purity & Documentation
References
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Description

DOTAGA.(SA.FAPi)2 TFA is a potent dimeric fibroblast-activation protein inhibitor (FAPi). DOTAGA.(SA.FAPi)2 TFA has the potential for cancer diagnosis research^[1].

Molecular Weight

1636.54

Formula

C₇₃H₈₄F₇N₁₇O₁₉

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(O)CN1CCN(C(CCC(NCCNC(C2=O)=C(NCCCCOC3=CC4=C(N=CC=C4C(NCC(N5[C@H](C#N)CC(C5)(F)F)=O)=O)C=C3)C2=O)=O)C(O)=O)CCN(CCN(CC1)CCNC(C6=O)=C(NCCCCOC7=CC8=C(N=CC=C8C(NCC(N9[C@H](C#N)CC(C9)(F)F)=O)=O)C=C7)C6=O)CC(O)=O.OC(C(F)(F)F)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (30.55 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.6110 mL	3.0552 mL	6.1105 mL
5 mM	0.1222 mL	0.6110 mL	1.2221 mL
10 mM	0.0611 mL	0.3055 mL	0.6110 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 96.81%

Select Batch:

Data Sheet (267 KB) SDS (252 KB)

COA (247 KB) LCMS (100 KB)

Handling Instructions (2659 KB)

References

[1]. Tilman Läppchen, et al. Tailoring Fibroblast-Activation Protein Targeting for Theranostics: A Comparative Preclinical Evaluation of the 68Ga- and 177Lu-Labeled Monomeric and Dimeric Fibroblast-Activation Protein Inhibitors DOTA.SA.FAPi and DOTAGA.(SA.FAPi)2. Molecules. 2024 Jun 28;29(13):3093. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.6110 mL	3.0552 mL	6.1105 mL	15.2761 mL
	5 mM	0.1222 mL	0.6110 mL	1.2221 mL	3.0552 mL
	10 mM	0.0611 mL	0.3055 mL	0.6110 mL	1.5276 mL
	15 mM	0.0407 mL	0.2037 mL	0.4074 mL	1.0184 mL
	20 mM	0.0306 mL	0.1528 mL	0.3055 mL	0.7638 mL
	25 mM	0.0244 mL	0.1222 mL	0.2444 mL	0.6110 mL
	30 mM	0.0204 mL	0.1018 mL	0.2037 mL	0.5092 mL