Doxapram hydrochloride hydrate

Name: Doxapram hydrochloride hydrate
Brand: MedChemExpress
SKU: HY-B0551A
Rating: 4.5 (1 reviews)

Cat. No.: HY-B0551A Purity: 99.34%: FAQs
Data Sheet SDS COA Handling Instructions

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Doxapram hydrochloride hydrate inhibits TASK-1, TASK-3, TASK-1/TASK-3 heterodimeric channel function with EC50 of 410 nM, 37 μM, 9 μM, respectively.

For research use only. We do not sell to patients.

Doxapram hydrochloride hydrate Chemical Structure

CAS No. : 7081-53-0

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10 mg	USD 25	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 45	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 65	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 100	In-stock	Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Doxapram hydrochloride hydrate:

Doxapram Get quote
Doxapram hydrochloride hydrate (Standard) Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Doxapram hydrochloride hydrate inhibits TASK-1, TASK-3, TASK-1/TASK-3 heterodimeric channel function with EC50 of 410 nM, 37 μM, 9 μM, respectively. Target: Potassium Channel Doxapram is a respiratory stimulant. Doxapram (15-150 microM) also evoked 3H overflow in a concentration dependent manner, and doxapram-evoked release was inhibited by the Ca2+ channel blocker nifedipine (5 microM). Analysis of released tritiated compounds suggested that doxapram preferentially stimulated the release of dopamine. Our results indicate that the mechanism of action of doxapram shares similarities with that of hypoxia in the carotid body [1]. Doxapram (1-100 microM) caused rapid, reversible and dose-dependent inhibitions of K+ currents recorded in type I cells (IC50 approximately 13 microM). doxapram was also seen to directly inhibit Ca(2+)-independent K+ currents. Doxapram was a more potent inhibitor of the Ca(2+)-activated K+ currents recorded under control conditions. Doxapram (10 microM) was without effect on L-type Ca2+ channel currents recorded under conditions where K+ channel activity was minimized and was also without significant effect on K+ currents recorded in the neuronal cell line NG-108 15, suggesting a selective effect on carotid body type I cells. The effects of doxapram on type I cells show similarities to those of the physiological stimuli of the carotid body, suggesting that doxapram may share a similar mechanism of action in stimulating the intact organ [2].

Clinical Trial

Molecular Weight

432.98

Formula

C₂₄H₃₃ClN₂O₃

CAS No.

7081-53-0

Appearance

Solid

Color

White to off-white

SMILES

O=C1N(CC)CC(CCN2CCOCC2)C1(C3=CC=CC=C3)C4=CC=CC=C4.Cl.O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : ≥ 55 mg/mL (127.03 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 25 mg/mL (57.74 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3096 mL	11.5479 mL	23.0958 mL
5 mM	0.4619 mL	2.3096 mL	4.6192 mL
10 mM	0.2310 mL	1.1548 mL	2.3096 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.34%

Select Batch:

Data Sheet (281 KB) SDS (420 KB)

COA (261 KB) LCMS (258 KB)

Handling Instructions (2659 KB)

References

[1]. Cotten JF, et al. The ventilatory stimulant doxapram inhibits TASK tandem pore (K2P) potassium channel function but does not affect minimum alveolar anesthetic concentration. Anesth Analg, 2006, 102(3), 779-785. [Content Brief]

[2]. Anderson-Beck, R., et al., Doxapram stimulates dopamine release from the intact rat carotid body in vitro. Neurosci Lett, 1995. 187(1): p. 25-8. [Content Brief]

[3]. Peers, C., Effects of doxapram on ionic currents recorded in isolated type I cells of the neonatal rat carotid body. Brain Res, 1991. 568(1-2): p. 116-22. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	2.3096 mL	11.5479 mL	23.0958 mL	57.7394 mL
	5 mM	0.4619 mL	2.3096 mL	4.6192 mL	11.5479 mL
	10 mM	0.2310 mL	1.1548 mL	2.3096 mL	5.7739 mL
	15 mM	0.1540 mL	0.7699 mL	1.5397 mL	3.8493 mL
	20 mM	0.1155 mL	0.5774 mL	1.1548 mL	2.8870 mL
	25 mM	0.0924 mL	0.4619 mL	0.9238 mL	2.3096 mL
	30 mM	0.0770 mL	0.3849 mL	0.7699 mL	1.9246 mL
	40 mM	0.0577 mL	0.2887 mL	0.5774 mL	1.4435 mL
	50 mM	0.0462 mL	0.2310 mL	0.4619 mL	1.1548 mL
DMSO	60 mM	0.0385 mL	0.1925 mL	0.3849 mL	0.9623 mL
	80 mM	0.0289 mL	0.1443 mL	0.2887 mL	0.7217 mL
	100 mM	0.0231 mL	0.1155 mL	0.2310 mL	0.5774 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.