2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. Doxapram hydrochloride hydrate

Doxapram hydrochloride hydrate 

Cat. No.: HY-B0551A Purity: 99.34%
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Doxapram hydrochloride hydrate inhibits TASK-1, TASK-3, TASK-1/TASK-3 heterodimeric channel function with EC50 of 410 nM, 37 μM, 9 μM, respectively.

For research use only. We do not sell to patients.

Doxapram hydrochloride hydrate Chemical Structure

Doxapram hydrochloride hydrate Chemical Structure

CAS No. : 7081-53-0

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Based on 1 publication(s) in Google Scholar

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Description

Doxapram hydrochloride hydrate inhibits TASK-1, TASK-3, TASK-1/TASK-3 heterodimeric channel function with EC50 of 410 nM, 37 μM, 9 μM, respectively. Target: Potassium Channel Doxapram is a respiratory stimulant. Doxapram (15-150 microM) also evoked 3H overflow in a concentration dependent manner, and doxapram-evoked release was inhibited by the Ca2+ channel blocker nifedipine (5 microM). Analysis of released tritiated compounds suggested that doxapram preferentially stimulated the release of dopamine. Our results indicate that the mechanism of action of doxapram shares similarities with that of hypoxia in the carotid body [1]. Doxapram (1-100 microM) caused rapid, reversible and dose-dependent inhibitions of K+ currents recorded in type I cells (IC50 approximately 13 microM). doxapram was also seen to directly inhibit Ca(2+)-independent K+ currents. Doxapram was a more potent inhibitor of the Ca(2+)-activated K+ currents recorded under control conditions. Doxapram (10 microM) was without effect on L-type Ca2+ channel currents recorded under conditions where K+ channel activity was minimized and was also without significant effect on K+ currents recorded in the neuronal cell line NG-108 15, suggesting a selective effect on carotid body type I cells. The effects of doxapram on type I cells show similarities to those of the physiological stimuli of the carotid body, suggesting that doxapram may share a similar mechanism of action in stimulating the intact organ [2].

Clinical Trial
Molecular Weight

432.98

Formula

C24H33ClN2O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1N(CC)CC(CCN2CCOCC2)C1(C3=CC=CC=C3)C4=CC=CC=C4.Cl.O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 55 mg/mL (127.03 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 25 mg/mL (57.74 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3096 mL 11.5479 mL 23.0958 mL
5 mM 0.4619 mL 2.3096 mL 4.6192 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 2.3096 mL 11.5479 mL 23.0958 mL 57.7394 mL
5 mM 0.4619 mL 2.3096 mL 4.6192 mL 11.5479 mL
10 mM 0.2310 mL 1.1548 mL 2.3096 mL 5.7739 mL
15 mM 0.1540 mL 0.7699 mL 1.5397 mL 3.8493 mL
20 mM 0.1155 mL 0.5774 mL 1.1548 mL 2.8870 mL
25 mM 0.0924 mL 0.4619 mL 0.9238 mL 2.3096 mL
30 mM 0.0770 mL 0.3849 mL 0.7699 mL 1.9246 mL
40 mM 0.0577 mL 0.2887 mL 0.5774 mL 1.4435 mL
50 mM 0.0462 mL 0.2310 mL 0.4619 mL 1.1548 mL
DMSO 60 mM 0.0385 mL 0.1925 mL 0.3849 mL 0.9623 mL
80 mM 0.0289 mL 0.1443 mL 0.2887 mL 0.7217 mL
100 mM 0.0231 mL 0.1155 mL 0.2310 mL 0.5774 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Doxapram hydrochloride hydrate Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Doxapram hydrochloride7081-53-0Potassium ChannelKcsAInhibitorinhibitorinhibit

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