Doxepin-d₃ hydrochloride

Name: Doxepin-d 3 hydrochloride
Brand: MedChemExpress
SKU: HY-B0725S
Rating: 4.5 (1 reviews)

Cat. No.: HY-B0725S Purity: 98.68%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Doxepin-d₃ (hydrochloride) is a deuterium labeled Doxepin Hydrochloride. Doxepin hydrochloride is an orally active tricyclic antidepressant. Doxepin hydrochloride is a potent and selective histamine receptor H1 antagonist. Doxepin hydrochloride is also a potent CYP450 inhibitor and significantly inhibits CYP450 2C19 and 1A2[1][2].

For research use only. We do not sell to patients.

Doxepin-d<sub>3</sub> hydrochloride Chemical Structure

Doxepin-d₃ hydrochloride Chemical Structure

CAS No. : 347840-07-7

Size	Price	Stock	Quantity
1 mg	USD 150	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 370	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 640	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Doxepin-d₃ hydrochloride:

Doxepin Hydrochloride In-stock
Doxepin Get quote
Doxepin-d3 Get quote

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•Related Small Molecules:

•Related Proteins:

View All Histamine Receptor Isoform Specific Products:

View All Isoforms

H₁ Receptor H₂ Receptor H₃ Receptor H₄ Receptor Histamine Receptor

View All Cytochrome P450 Isoform Specific Products:

View All Isoforms

CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

Histamine receptor H1; CYP450 2C19 and CYP450 1A2^[2]

Molecular Weight

318.86

Formula

C₁₉H₁₉D₃ClNO

CAS No.

347840-07-7

Unlabeled CAS

1229-29-4

Appearance

Solid

Color

Off-white to light yellow

SMILES

[2H]C(N(C)CC/C=C1C2=CC=CC=C2OCC3=CC=CC=C\13)([2H])[2H].[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (313.62 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : ≥ 50 mg/mL (156.81 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.1362 mL	15.6809 mL	31.3617 mL
5 mM	0.6272 mL	3.1362 mL	6.2723 mL
10 mM	0.3136 mL	1.5681 mL	3.1362 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 98.68%

Select Batch:

Data Sheet (277 KB) SDS (251 KB)

COA (256 KB) HNMR (122 KB) LCMS (85 KB)

Handling Instructions (2659 KB)

References

[1]. Hajak, G., et al., Doxepin in the treatment of primary insomnia: a placebo-controlled, double-blind, polysomnographic study. J Clin Psychiatry, 2001. 62(6): p. 453-63. [Content Brief]

[2]. Gillman PK1. Tricyclic antidepressant pharmacology and therapeutic drug interactions updated. Br J Pharmacol. 2007 Jul;151(6):737-48. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / H₂O / DMSO / DMSO	1 mM	3.1362 mL	15.6809 mL	31.3617 mL	78.4043 mL
	5 mM	0.6272 mL	3.1362 mL	6.2723 mL	15.6809 mL
	10 mM	0.3136 mL	1.5681 mL	3.1362 mL	7.8404 mL
	15 mM	0.2091 mL	1.0454 mL	2.0908 mL	5.2270 mL
	20 mM	0.1568 mL	0.7840 mL	1.5681 mL	3.9202 mL
	25 mM	0.1254 mL	0.6272 mL	1.2545 mL	3.1362 mL
	30 mM	0.1045 mL	0.5227 mL	1.0454 mL	2.6135 mL
	40 mM	0.0784 mL	0.3920 mL	0.7840 mL	1.9601 mL
	50 mM	0.0627 mL	0.3136 mL	0.6272 mL	1.5681 mL
	60 mM	0.0523 mL	0.2613 mL	0.5227 mL	1.3067 mL
	80 mM	0.0392 mL	0.1960 mL	0.3920 mL	0.9801 mL
	100 mM	0.0314 mL	0.1568 mL	0.3136 mL	0.7840 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.