2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. Droxidopa

Droxidopa  (Synonyms: L-DOPS; DOPS; SM5688)

Cat. No.: HY-13458 Purity: 96.12%
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Droxidopa (L-DOPS; SM5688) is a potent, orally active norepinephrine precursor. Droxidopa increases standing blood pressure, ameliorates symptoms of orthostatic hypotension and improves standing ability. Droxidopa has the potential for the research of neurogenic orthostatic hypotension (nOH) and alternative ADHD (attention deficit hyperactivity disorder).

For research use only. We do not sell to patients.

Droxidopa Chemical Structure

Droxidopa Chemical Structure

CAS No. : 23651-95-8

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Based on 1 publication(s) in Google Scholar

Other Forms of Droxidopa:

Droxidopa Related Antibodies

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Description

Droxidopa (L-DOPS; SM5688) is a potent, orally active norepinephrine precursor. Droxidopa increases standing blood pressure, ameliorates symptoms of orthostatic hypotension and improves standing ability. Droxidopa has the potential for the research of neurogenic orthostatic hypotension (nOH) and alternative ADHD (attention deficit hyperactivity disorder)[1][2][3][4].

In Vivo

Droxidopa (200 mg/kg;i.p.) alters dopamine neuron and prefrontal cortex activity and improves attention-deficit/hyperactivity disorder-like behaviors in rats[2]. Droxidopa (10, 20 mg/kg; i.p.) significantly increases the paw withdrawal latency and inhibits mechanical hypersensitivity to thermal stimulation in 6-OHDA-lesioned rats at the 5th week after surgery[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 250-380g male Sprague-Dawley rats[2]
Dosage: 200 mg/kg (10 mg/kg, i.p. benserazide was given to the animals at 20 or 30 min prior to L-DOPS injection)
Administration: I.p.
Result: Significantly decreased hyperactivity of BZ-pretreated SHR/NCrl at 30 (P < 0.01) and 40 min (P < 0.05) post-injection, improved inattention-like behavior of SHR/NCrl, and ameliorated impulsive-like behavior of SHR/NCrl and Wistar rats.
Clinical Trial
Molecular Weight

213.19

Formula

C9H11NO5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC1=C(O)C=CC([C@@H](O)[C@@H](C(O)=O)N)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : < 1 mg/mL (insoluble or slightly soluble)

H2O : < 0.1 mg/mL (insoluble)

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Purity & Documentation

Purity: 96.12%

COA (231 KB) RP-HPLC (254 KB)

Handling Instructions (2659 KB)
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Droxidopa Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Droxidopa23651-95-8L-DOPS DOPS SM5688SM5688SM 5688SM-5688Adrenergic ReceptorBeta Receptororally activeblood pressureneurogenic orthostatic hypotensionADHDInhibitorinhibitorinhibit

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