2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. DS2

DS2 is a selective positive allosteric modulator of δ-GABAA receptor. DS2 selectively potentiates GABA responses mediated by α4β3δ receptor. DS2 does not enhance activity at α4β3γ2 and α1β3γ2 receptors. DS2 relieves pain and has the potential for sleep disorders research.

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DS2 Chemical Structure

DS2 Chemical Structure

CAS No. : 374084-31-8

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10 mg USD 550 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

DS2 is a selective positive allosteric modulator of δ-GABAA receptor. DS2 selectively potentiates GABA responses mediated by α4β3δ receptor. DS2 does not enhance activity at α4β3γ2 and α1β3γ2 receptors. DS2 relieves pain and has the potential for sleep disorders research[1].

Molecular Weight

353.83

Formula

C18H12ClN3OS
CAS No.
Appearance

Solid

Color

Off-white to light brown

SMILES

O=C(NC1=C(C2=CC=CS2)N=C3C=CC=CN31)C4=CC=C(Cl)C=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (353.28 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8262 mL 14.1311 mL 28.2622 mL
5 mM 0.5652 mL 2.8262 mL 5.6524 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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V2

In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8262 mL 14.1311 mL 28.2622 mL 70.6554 mL
5 mM 0.5652 mL 2.8262 mL 5.6524 mL 14.1311 mL
10 mM 0.2826 mL 1.4131 mL 2.8262 mL 7.0655 mL
15 mM 0.1884 mL 0.9421 mL 1.8841 mL 4.7104 mL
20 mM 0.1413 mL 0.7066 mL 1.4131 mL 3.5328 mL
25 mM 0.1130 mL 0.5652 mL 1.1305 mL 2.8262 mL
30 mM 0.0942 mL 0.4710 mL 0.9421 mL 2.3552 mL
40 mM 0.0707 mL 0.3533 mL 0.7066 mL 1.7664 mL
50 mM 0.0565 mL 0.2826 mL 0.5652 mL 1.4131 mL
60 mM 0.0471 mL 0.2355 mL 0.4710 mL 1.1776 mL
80 mM 0.0353 mL 0.1766 mL 0.3533 mL 0.8832 mL
100 mM 0.0283 mL 0.1413 mL 0.2826 mL 0.7066 mL
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DS2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DS2374084-31-8DS 2DS-2GABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid Receptorpositive allosteric modulatorδ-GABAAα4β3δα4β3γ2α1β3γ2pain,?sleep disordersInhibitorinhibitorinhibit

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