2. Metabolic Enzyme/Protease
  3. Methylenetetrahydrofolate Dehydrogenase (MTHFD)
  4. DS44960156

DS44960156 is a selective Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) inhibitor, with IC50 values of 1.6 μM and >30 μM for MTHFD2 and MTHFD1, respectively.

For research use only. We do not sell to patients.

DS44960156 Chemical Structure

DS44960156 Chemical Structure

CAS No. : 2361327-08-2

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 231 In-stock
Solution
10 mM * 1 mL in DMSO USD 231 In-stock
Solid
1 mg USD 84 In-stock
5 mg USD 210 In-stock
10 mg USD 320 In-stock
25 mg USD 550 In-stock
50 mg USD 800 In-stock
100 mg USD 1150 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

DS44960156 is a selective Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) inhibitor, with IC50 values of 1.6 μM and >30 μM for MTHFD2 and MTHFD1, respectively[1].

IC50 & Target

IC50: 1.6 μM (MTHFD2), >30 μM (MTHFD1)[1].
Molecular Weight

349.34

Formula

C20H15NO5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)C1=CC=C(C(N2CCC(C3=CC=CC=C3O4)=C(C4=O)C2)=O)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (286.25 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8625 mL 14.3127 mL 28.6254 mL
5 mM 0.5725 mL 2.8625 mL 5.7251 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.36%

COA (248 KB) HNMR (139 KB) RP-HPLC (246 KB) LCMS (382 KB) Elemental Analysis Report (107 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8625 mL 14.3127 mL 28.6254 mL 71.5635 mL
5 mM 0.5725 mL 2.8625 mL 5.7251 mL 14.3127 mL
10 mM 0.2863 mL 1.4313 mL 2.8625 mL 7.1564 mL
15 mM 0.1908 mL 0.9542 mL 1.9084 mL 4.7709 mL
20 mM 0.1431 mL 0.7156 mL 1.4313 mL 3.5782 mL
25 mM 0.1145 mL 0.5725 mL 1.1450 mL 2.8625 mL
30 mM 0.0954 mL 0.4771 mL 0.9542 mL 2.3855 mL
40 mM 0.0716 mL 0.3578 mL 0.7156 mL 1.7891 mL
50 mM 0.0573 mL 0.2863 mL 0.5725 mL 1.4313 mL
60 mM 0.0477 mL 0.2385 mL 0.4771 mL 1.1927 mL
80 mM 0.0358 mL 0.1789 mL 0.3578 mL 0.8945 mL
100 mM 0.0286 mL 0.1431 mL 0.2863 mL 0.7156 mL
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DS44960156 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DS449601562361327-08-2DS 44960156DS-44960156Methylenetetrahydrofolate Dehydrogenase (MTHFD)Inhibitorinhibitorinhibit

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