2. Antibody-drug Conjugate/ADC Related Apoptosis Metabolic Enzyme/Protease Cell Cycle/DNA Damage
  3. Peptide-Drug Conjugate (PDC) Apoptosis HSP Eukaryotic Initiation Factor (eIF) PERK
  4. DTX-P7

DTX-P7 is a peptide-drug conjugate. DTX-P7, composed of Docetaxel (DTX, HY-B0011) and a heptapeptide (P7), induces unfolded protein response and subsequent apoptosis by degrading Hsp90.

For research use only. We do not sell to patients.

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DTX-P7 Chemical Structure

DTX-P7 Chemical Structure

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DTX-P7 Related Antibodies

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HSP40 HSP70 HSP90 HSP105 HSF1 HSP HSPA5

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Description

DTX-P7 is a peptide-drug conjugate. DTX-P7, composed of Docetaxel (DTX, HY-B0011) and a heptapeptide (P7), induces unfolded protein response and subsequent apoptosis by degrading Hsp90[1].
Cellular Effect
Cell Line Type Value Description References
A549 IC50
11.4 nM
PMID: 35659720
H1975 IC50
0.62 nM
PMID: 35659720
In Vitro

DTX-P7 inhibits the expression of membrane Hsp90 in dose- and time-dependent manners, while no change in mRNA level is observed[1].
DTX-P7 enhances phosphorylation of PERK and eIF2α, whereas no XBP-1 RNA splicing is observed when A549 cells are exposed[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DTX-P7 Related Antibodies
In Vivo

DTX-P7 (mice implanted with A549 xenograft tumor, 15/30 mg/kg, once a week for 4 weeks) suppresses tumor growth of quiescent/slowly proliferating A549/CD133+ cells via degradation of DYRK1A and subsequent cell cycle reentry[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

1639.87

Formula

C84H118N8O25
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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DTX-P7 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DTX-P7Peptide-Drug Conjugate (PDC)ApoptosisHSPEukaryotic Initiation Factor (eIF)PERKHeat shock proteinsProtein kinase R-like endoplasmic reticulum kinasePKR-like endoplasmic reticulum kinaseA549NSCLCCSLCHsp90Non-small cell lung cancerHeat shock protein 90 (Hsp90)Cancer stem-like cells (CSLCs)Cell cycle reentryDormancyTargeting deliveryUnfolded protein responseInhibitorinhibitorinhibit

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HY-P10757
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