2. Immunology/Inflammation
  3. IRAK
  4. DW18134

DW18134 is an inhibitor for interleukin receptor-associated kinase 4 (IRAK 4) with an IC50 of 11.2 nM. DW18134 inhibits phosphorylation of IRAK4 and IKK, downregulates the secretion of TNF-α and IL-6. DW18134 attenuates the Lipopolysaccharides (HY-D1056)-induced peritonitis and DSS-induced colitis in mouse models, and protects the intestinal barrier function .

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DW18134 Chemical Structure

DW18134 Chemical Structure

CAS No. : 2626988-87-0

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DW18134 Related Antibodies

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IRAK1 IRAK4

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Description

DW18134 is an inhibitor for interleukin receptor-associated kinase 4 (IRAK 4) with an IC50 of 11.2 nM. DW18134 inhibits phosphorylation of IRAK4 and IKK, downregulates the secretion of TNF-α and IL-6. DW18134 attenuates the Lipopolysaccharides (HY-D1056)-induced peritonitis and DSS-induced colitis in mouse models, and protects the intestinal barrier function [1].

IC50 & Target

IRAK4

11.2 nM (IC50)

Molecular Weight

427.46

Formula

C24H21N5O3
CAS No.
SMILES

CC(O1)(C)CC2=C1C=C(C3=CC=NC=C3)C(NC(C4=COC(C5=CC(N)=NC=C5)=N4)=O)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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DW18134 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DW181342626988-87-0DW 18134DW-18134IRAKInterleukin-1 receptor associated kinaseIL-1R associated kinaseRAW264.7peritonitiscolitisinflammatory bowel diseaseIBDBALB/c mouseInhibitorinhibitorinhibit

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