2. Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  3. PPAR
  4. E0924G

E0924G is an orally active activator for PPARδ with EC50 of 2.82 μM. E0924G promotes the upregulation of osteoprotegerin (OPG) with an EC50 of 0.29 μM. E0924G reduces RANKL-induced osteoclast differentiation and inhibites F-actin ring formation in RAW264.7 macrophages. E0924G regulates the bone density and bone loss in ovariectomized (OVX) and age-related osteoporosis models.

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E0924G Chemical Structure

E0924G Chemical Structure

CAS No. : 2909474-29-7

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E0924G Related Antibodies

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Description

E0924G is an orally active activator for PPARδ with EC50 of 2.82 μM. E0924G promotes the upregulation of osteoprotegerin (OPG) with an EC50 of 0.29 μM. E0924G reduces RANKL-induced osteoclast differentiation and inhibites F-actin ring formation in RAW264.7 macrophages. E0924G regulates the bone density and bone loss in ovariectomized (OVX) and age-related osteoporosis models[1].

IC50 & Target

PPARδ

2.82 μM (EC50)

Molecular Weight

232.24

Formula

C12H12N2O3
CAS No.
SMILES

O=C(C1=CC=C(C)O1)NC2=NC=CC(OC)=C2
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Storage

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Purity & Documentation
References
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E0924G Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

E0924G2909474-29-7PPARPeroxisome proliferator-activated receptorsMC3T3-E1osteoporosisRAW264.7orally activeSprague-Dawley’s ratSAMP6 mouseInhibitorinhibitorinhibit

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