2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. Pomalidomide-C2-NH2 hydrochloride

Pomalidomide-C2-NH2 hydrochloride  (Synonyms: Cereblon Ligand-Linker Conjugates 15 hydrochloride)

Cat. No.: HY-128846A Purity: 99.46%
SDS COA Handling Instructions

Molarity Calculator

Pomalidomide-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology.

For research use only. We do not sell to patients.

Pomalidomide-C2-NH2 hydrochloride Chemical Structure

Pomalidomide-C2-NH2 hydrochloride Chemical Structure

CAS No. : 2305369-00-8

Size Price Stock Quantity
5 mg USD 65 In-stock
10 mg USD 100 In-stock
25 mg USD 210 In-stock
50 mg USD 280 In-stock
100 mg USD 380 In-stock
250 mg USD 580 In-stock
500 mg   Get quote  
1 g   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Pomalidomide-C2-NH2 hydrochloride:

Pomalidomide-C2-NH2 hydrochloride Related Antibodies

Top Publications Citing Use of Products

View All E3 Ligase Ligand-Linker Conjugates Isoform Specific Products:

View All Isoforms
von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor TRIM21

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Pomalidomide-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology.

IC50 & Target

Cereblon

 

Molecular Weight

352.77

Formula

C15H17ClN4O4
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3NCCN)=O.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (354.34 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8347 mL 14.1735 mL 28.3471 mL
5 mM 0.5669 mL 2.8347 mL 5.6694 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.46%

SDS (393 KB)

COA (248 KB) HNMR (132 KB) LCMS (95 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8347 mL 14.1735 mL 28.3471 mL 70.8677 mL
5 mM 0.5669 mL 2.8347 mL 5.6694 mL 14.1735 mL
10 mM 0.2835 mL 1.4174 mL 2.8347 mL 7.0868 mL
15 mM 0.1890 mL 0.9449 mL 1.8898 mL 4.7245 mL
20 mM 0.1417 mL 0.7087 mL 1.4174 mL 3.5434 mL
25 mM 0.1134 mL 0.5669 mL 1.1339 mL 2.8347 mL
30 mM 0.0945 mL 0.4725 mL 0.9449 mL 2.3623 mL
40 mM 0.0709 mL 0.3543 mL 0.7087 mL 1.7717 mL
50 mM 0.0567 mL 0.2835 mL 0.5669 mL 1.4174 mL
60 mM 0.0472 mL 0.2362 mL 0.4725 mL 1.1811 mL
80 mM 0.0354 mL 0.1772 mL 0.3543 mL 0.8858 mL
100 mM 0.0283 mL 0.1417 mL 0.2835 mL 0.7087 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Pomalidomide-C2-NH2 hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pomalidomide-C2-NH22305369-00-8Cereblon Ligand-Linker Conjugates 15E3 Ligase Ligand-Linker ConjugatesInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Pomalidomide-C2-NH2 hydrochloride
Cat. No.:
HY-128846A
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (393 KB) Français - FR (393 KB) Deutsch - DE (393 KB) Norwegian - NO (393 KB) Español - ES (393 KB) Swedish - SV (393 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.