2. Peptides
  3. Peptide and Derivatives
  4. Therapeutic Peptides
  5. EA-230

EA-230 is a synthetic oligopeptide originally derived from beta-human chorionic gonadotropin (beta-hCG) lysates. EA-230 has anti-inflammatory effects and can be used for the research of sepsis.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

EA-230 Chemical Structure

EA-230 Chemical Structure

CAS No. : 503844-09-5

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5 mg USD 65 In-stock
10 mg USD 100 In-stock
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Based on 1 publication(s) in Google Scholar

EA-230 Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

EA-230 is a synthetic oligopeptide originally derived from beta-human chorionic gonadotropin (beta-hCG) lysates. EA-230 has anti-inflammatory effects and can be used for the research of sepsis[1].

In Vivo

EA-230 (30-50 mg/kg; i.p.; twice daily for four consecutive days) improves survival and attenuate loss of kidney function in a mouse model of renal ischemia/reperfusion injury (IRI) and ischemia-induced delayed graft function after allogenic kidney transplantation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57Bl/6 mice, ischemia reperfusion injury model[1]
Dosage: 20, 30, 40 or 50 mg/kg
Administration: Intraperitoneal injection, twice daily for four consecutive days
Result: Improved survival markedly. With doses between 30–50 mg/kg survival reached 56–62%, the low dose treatment with 20 mg/kg did not have a beneficial effect. Significantly increased renal blood flow (RBF), attenuated CTGF up-regulation, enhanced tubular epithelial cell regeneration and attenuated TGF-beta activation.
Clinical Trial
Molecular Weight

373.40

Formula

C15H27N5O6
CAS No.
Appearance

Solid

Color

White to off-white

Sequence Shortening

AQGV
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (334.76 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6781 mL 13.3905 mL 26.7809 mL
5 mM 0.5356 mL 2.6781 mL 5.3562 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6781 mL 13.3905 mL 26.7809 mL 66.9523 mL
5 mM 0.5356 mL 2.6781 mL 5.3562 mL 13.3905 mL
10 mM 0.2678 mL 1.3390 mL 2.6781 mL 6.6952 mL
15 mM 0.1785 mL 0.8927 mL 1.7854 mL 4.4635 mL
20 mM 0.1339 mL 0.6695 mL 1.3390 mL 3.3476 mL
25 mM 0.1071 mL 0.5356 mL 1.0712 mL 2.6781 mL
30 mM 0.0893 mL 0.4463 mL 0.8927 mL 2.2317 mL
40 mM 0.0670 mL 0.3348 mL 0.6695 mL 1.6738 mL
50 mM 0.0536 mL 0.2678 mL 0.5356 mL 1.3390 mL
60 mM 0.0446 mL 0.2232 mL 0.4463 mL 1.1159 mL
80 mM 0.0335 mL 0.1674 mL 0.3348 mL 0.8369 mL
100 mM 0.0268 mL 0.1339 mL 0.2678 mL 0.6695 mL
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EA-230 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EA-230503844-09-5EA230EA 230Othersoligopeptidebeta-hCGbeta-human chorionic gonadotropinanti-inflammatorysepsisischemia reperfusion injury modelIRIAQGVInhibitorinhibitorinhibit

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