2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. EGFR/HER2-IN-2

EGFR/HER2-IN-2 (Compound ZINC35560729) is a dual inhibitor of EGFR and HER2 with IC50 values of 5.02 µM and 0.83 µM against EGFR and HER2, respectively.

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EGFR/HER2-IN-2 Chemical Structure

EGFR/HER2-IN-2 Chemical Structure

CAS No. : 1215571-02-0

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EGFR/HER2-IN-2 Related Antibodies

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

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Description

EGFR/HER2-IN-2 (Compound ZINC35560729) is a dual inhibitor of EGFR and HER2 with IC50 values of 5.02 µM and 0.83 µM against EGFR and HER2, respectively[1].

IC50 & Target

HER2

0.83 μM (IC50)

EGFR

5.02 μM (IC50)

Molecular Weight

453.49

Formula

C26H23N5O3
CAS No.
SMILES

COC1=CC=C(C2=NN=C(C3=NC(NCC4=CC=CC=C4OCC)=C5C=CC=CC5=N3)O2)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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EGFR/HER2-IN-2 Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EGFR/HER2-IN-21215571-02-0EGFREpidermal growth factor receptorErbB-1HER1antitumorInhibitorinhibitorinhibit

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