2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. EGFR-IN-126

EGFR-IN-126 (compound 9d) is a potent inhibitor of EGFRL858R/T790M/C797S, with the IC50 value of 0.005 μM. EGFR-IN-126 shows antitumor effects in vivo and in vitro.

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EGFR-IN-126 Chemical Structure

EGFR-IN-126 Chemical Structure

CAS No. : 2890621-88-0

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EGFR-IN-126 Related Antibodies

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Description

EGFR-IN-126 (compound 9d) is a potent inhibitor of EGFRL858R/T790M/C797S, with the IC50 value of 0.005 μM. EGFR-IN-126 shows antitumor effects in vivo and in vitro[1].

Molecular Weight

567.45

Formula

C28H28BrFN4O3
CAS No.
SMILES

COC1=C(OCC2CCN(C)CC2)C=C(N=CN=C3NC4=CC=C(OC5=CC=CC=C5F)C(Br)=C4)C3=C1
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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EGFR-IN-126 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EGFR-IN-1262890621-88-0EGFREpidermal growth factor receptorErbB-1HER1BaF3 cell xenograft modelInhibitorinhibitorinhibit

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