2. Apoptosis Protein Tyrosine Kinase/RTK JAK/STAT Signaling
  3. Apoptosis EGFR
  4. EGFR-IN-78

EGFR-IN-78 (compound A5)，a 2-aminopyrimidine derivative，is a reversible inhibitor of EGFRC797S-TK，and also an inducer of apoptosis. EGFR-IN-78 shows anti-proliferative activity，inhibits EGFR phosphorylation and arrests cell cycle at G2/M phase.

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EGFR-IN-78 Chemical Structure

EGFR-IN-78 Chemical Structure

CAS No. : 3042104-73-1

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
5 mg In-stock
10 mg In-stock
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Based on 1 publication(s) in Google Scholar

EGFR-IN-78 Related Antibodies

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Description

EGFR-IN-78 (compound A5)，a 2-aminopyrimidine derivative，is a reversible inhibitor of EGFRC797S-TK，and also an inducer of apoptosis. EGFR-IN-78 shows anti-proliferative activity，inhibits EGFR phosphorylation and arrests cell cycle at G2/M phase[1].

IC50 & Target

EGFRC797S[1]
Molecular Weight

550.51

Formula

C23H32BrN7O2S
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

BrC1=C(N[C@@H]2CCCN(S(C3CC3)(=O)=O)C2)N=C(NC4=CC=C(N5CCN(C)CC5)C=C4)N=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (181.65 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8165 mL 9.0825 mL 18.1650 mL
5 mM 0.3633 mL 1.8165 mL 3.6330 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8165 mL 9.0825 mL 18.1650 mL 45.4124 mL
5 mM 0.3633 mL 1.8165 mL 3.6330 mL 9.0825 mL
10 mM 0.1816 mL 0.9082 mL 1.8165 mL 4.5412 mL
15 mM 0.1211 mL 0.6055 mL 1.2110 mL 3.0275 mL
20 mM 0.0908 mL 0.4541 mL 0.9082 mL 2.2706 mL
25 mM 0.0727 mL 0.3633 mL 0.7266 mL 1.8165 mL
30 mM 0.0605 mL 0.3027 mL 0.6055 mL 1.5137 mL
40 mM 0.0454 mL 0.2271 mL 0.4541 mL 1.1353 mL
50 mM 0.0363 mL 0.1816 mL 0.3633 mL 0.9082 mL
60 mM 0.0303 mL 0.1514 mL 0.3027 mL 0.7569 mL
80 mM 0.0227 mL 0.1135 mL 0.2271 mL 0.5677 mL
100 mM 0.0182 mL 0.0908 mL 0.1816 mL 0.4541 mL
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EGFR-IN-78 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EGFR-IN-783042104-73-1ApoptosisEGFREpidermal growth factor receptorErbB-1HER1Inhibitorinhibitorinhibit

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