2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. EGFR kinase inhibitor 3

EGFR kinase inhibitor 3 (compound 2) is a bivalent ATP-allosteric EGFR kinase inhibitor with IC50s of <10 nM, 1.5 nM, 0.059 nM, 0.064 nM for WT EGFR, EGFR-activating mutations L858R, L858R/T790M and L858R/T790M/C797S, respectively. EGFR kinase inhibitor 3 is a C-linked inhibitor.

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EGFR kinase inhibitor 3 Chemical Structure

EGFR kinase inhibitor 3 Chemical Structure

CAS No. : 2922402-03-5

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Based on 1 publication(s) in Google Scholar

EGFR kinase inhibitor 3 Related Antibodies

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Description

EGFR kinase inhibitor 3 (compound 2) is a bivalent ATP-allosteric EGFR kinase inhibitor with IC50s of <10 nM, 1.5 nM, 0.059 nM, 0.064 nM for WT EGFR, EGFR-activating mutations L858R, L858R/T790M and L858R/T790M/C797S, respectively. EGFR kinase inhibitor 3 is a C-linked inhibitor[1].

IC50 & Target[1]

EGFR (WT)

<10 nM (IC50)

EGFR L858R

1.5 nM (IC50)

EGFR L858R/T790M

0.059 nM (IC50)

EGFR L858R/T790M/C797S

0.064 nM (IC50)

Molecular Weight

575.64

Formula

C31H25N7O3S
CAS No.
SMILES

O=C(NC1=CC=CC(C2=C(NC(SC)=N2)C3=CC=NC(NC(C)=O)=C3)=C1)C4=C5NC(C6=C(NC5=CC=C4)C=CC=C6)=O
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
References
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EGFR kinase inhibitor 3 Related Classifications

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Keywords:

EGFR kinase inhibitor 32922402-03-5EGFR kinase inhibitor3EGFR kinase inhibitor-3EGFREpidermal growth factor receptorErbB-1HER1BivalentATP-allostericL858RT790MC797SC-linkedInhibitorinhibitorinhibit

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