2. Neuronal Signaling Stem Cell/Wnt
  3. γ-secretase Amyloid-β
  4. ELND 006

ELND 006 (Compound 30) is a metabolically stable γ-secretase inhibitor designed to selectively inhibit amyloid beta (Aβ) generation while sparing Notch signaling. It was developed through a synthetic strategy emphasizing diversity and chirality. ELND 006, along with its analog ELND007 (Compound 34), progressed into human clinical trials. In preclinical studies, both compounds demonstrated effective reduction of Aβ levels in vitro and in vivo. Comparisons with other γ-secretase inhibitors like Semagacestat, Begacestat, and Avagacestat underscored their potency and specificity in lowering Aβ levels in cerebrospinal fluid (CSF) of healthy human volunteers, suggesting potential therapeutic efficacy in Alzheimer's disease.

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ELND 006 Chemical Structure

ELND 006 Chemical Structure

CAS No. : 1333990-84-3

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Based on 1 publication(s) in Google Scholar

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Description

ELND 006 (Compound 30) is a metabolically stable γ-secretase inhibitor designed to selectively inhibit amyloid beta (Aβ) generation while sparing Notch signaling. It was developed through a synthetic strategy emphasizing diversity and chirality. ELND 006, along with its analog ELND007 (Compound 34), progressed into human clinical trials. In preclinical studies, both compounds demonstrated effective reduction of Aβ levels in vitro and in vivo. Comparisons with other γ-secretase inhibitors like Semagacestat, Begacestat, and Avagacestat underscored their potency and specificity in lowering Aβ levels in cerebrospinal fluid (CSF) of healthy human volunteers, suggesting potential therapeutic efficacy in Alzheimer's disease[1].

Molecular Weight

455.40

Formula

C20H14F5N3O2S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=S(N1[C@H](C2CC2)C3=C(NN=C3)C4=C1C=C(F)C(F)=C4)(C5=CC=C(C(F)(F)F)C=C5)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (109.79 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1959 mL 10.9794 mL 21.9587 mL
5 mM 0.4392 mL 2.1959 mL 4.3917 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1959 mL 10.9794 mL 21.9587 mL 54.8968 mL
5 mM 0.4392 mL 2.1959 mL 4.3917 mL 10.9794 mL
10 mM 0.2196 mL 1.0979 mL 2.1959 mL 5.4897 mL
15 mM 0.1464 mL 0.7320 mL 1.4639 mL 3.6598 mL
20 mM 0.1098 mL 0.5490 mL 1.0979 mL 2.7448 mL
25 mM 0.0878 mL 0.4392 mL 0.8783 mL 2.1959 mL
30 mM 0.0732 mL 0.3660 mL 0.7320 mL 1.8299 mL
40 mM 0.0549 mL 0.2745 mL 0.5490 mL 1.3724 mL
50 mM 0.0439 mL 0.2196 mL 0.4392 mL 1.0979 mL
60 mM 0.0366 mL 0.1830 mL 0.3660 mL 0.9149 mL
80 mM 0.0274 mL 0.1372 mL 0.2745 mL 0.6862 mL
100 mM 0.0220 mL 0.1098 mL 0.2196 mL 0.5490 mL
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ELND 006 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ELND 0061333990-84-3ELND006ELND-006γ-secretaseAmyloid-βGamma secretaseβ-amyloid peptideAβAbetaInhibitorinhibitorinhibit

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