Empagliflozin-d₄ (Synonyms: BI 10773-d₄)

Name: Empagliflozin-d 4
Brand: MedChemExpress
SKU: HY-15409S
Rating: 4.5 (1 reviews)

Cat. No.: HY-15409S Purity: 97.64%: FAQs
Data Sheet SDS COA Handling Instructions

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Empagliflozin-d₄ is deuterium labeled Empagliflozin. Empagliflozin (BI 107730 is a selective sodium glucose cotransporter-2 (SGLT-2) inhibitor with an IC50 of 3.1 nM for human SGLT-2[1].

For research use only. We do not sell to patients.

Empagliflozin-d<sub>4</sub> Chemical Structure

Empagliflozin-d₄ Chemical Structure

CAS No. : 2749293-95-4

Size	Price	Stock	Quantity
1 mg	USD 350	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 950	In-stock	Estimated Time of Arrival: December 31
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50 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Empagliflozin In-stock

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Description

Empagliflozin-d₄ is deuterium labeled Empagliflozin. Empagliflozin (BI 107730 is a selective sodium glucose cotransporter-2 (SGLT-2) inhibitor with an IC50 of 3.1 nM for human SGLT-2[1].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

454.93

Formula

C₂₃H₂₃D₄ClO₇

CAS No.

2749293-95-4

Unlabeled CAS

864070-44-0

Appearance

Solid

Color

White to off-white

SMILES

ClC(C=CC([C@H]1[C@@H]([C@H]([C@@H]([C@H](O1)CO)O)O)O)=C2)=C2CC3=C(C([2H])=C(C([2H])=C3[2H])O[C@H]4CCOC4)[2H]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (109.91 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1981 mL	10.9907 mL	21.9814 mL
5 mM	0.4396 mL	2.1981 mL	4.3963 mL
10 mM	0.2198 mL	1.0991 mL	2.1981 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 97.64%

Select Batch:

Data Sheet (276 KB) SDS (251 KB)

COA (253 KB) HNMR (132 KB) LCMS (90 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Grempler R, et al. Empagliflozin, a novel selective sodium glucose cotransporter-2 (SGLT-2) inhibitor: characterisation and comparison with other SGLT-2 inhibitors. Diabetes Obes Metab. 2012 Jan;14(1):83-90. [Content Brief]

[3]. Cheng ST, et al. The Effects of Empagliflozin, an SGLT2 Inhibitor, on Pancreatic β-Cell Mass and Glucose Homeostasis in Type 1 Diabetes. PLoS One. 2016 Jan 25;11(1):e0147391. [Content Brief]

[4]. Nikole J.ByrneBSc, et al. Empagliflozin Prevents Worsening of Cardiac Function in an Experimental Model of Pressure Overload-Induced Heart Failure. JACC Basic Transl Sci. 2017 Aug;2(4):347-354.

[5]. Sakaeda T, et al. Susceptibility to serious skin and subcutaneous tissue disorders and skin tissue distribution of sodium-dependent glucose co-transporter type 2 (SGLT2) inhibitors. Int J Med Sci. 2018 Jun 13;15(9):937-943. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / DMSO	1 mM	2.1981 mL	10.9907 mL	21.9814 mL	54.9535 mL
	5 mM	0.4396 mL	2.1981 mL	4.3963 mL	10.9907 mL
	10 mM	0.2198 mL	1.0991 mL	2.1981 mL	5.4954 mL
	15 mM	0.1465 mL	0.7327 mL	1.4654 mL	3.6636 mL
	20 mM	0.1099 mL	0.5495 mL	1.0991 mL	2.7477 mL
	25 mM	0.0879 mL	0.4396 mL	0.8793 mL	2.1981 mL
	30 mM	0.0733 mL	0.3664 mL	0.7327 mL	1.8318 mL
	40 mM	0.0550 mL	0.2748 mL	0.5495 mL	1.3738 mL
	50 mM	0.0440 mL	0.2198 mL	0.4396 mL	1.0991 mL
	60 mM	0.0366 mL	0.1832 mL	0.3664 mL	0.9159 mL
	80 mM	0.0275 mL	0.1374 mL	0.2748 mL	0.6869 mL
	100 mM	0.0220 mL	0.1099 mL	0.2198 mL	0.5495 mL

Empagliflozin-d₄ Related Classifications

Metabolic Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Empagliflozin-d₄2749293-95-4BI 10773-d₄SGLTSodium-dependent glucose cotransportersInhibitorinhibitorinhibit

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Empagliflozin-d4 (Synonyms: BI 10773-d4)

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Empagliflozin-d₄ (Synonyms: BI 10773-d₄)

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Empagliflozin-d₄ Related Antibodies

Empagliflozin-d₄ Related Antibodies

Empagliflozin-d₄ Related Classifications