2. Anti-infection Metabolic Enzyme/Protease
  3. HIV Reverse Transcriptase Endogenous Metabolite
  4. Emtricitabine-15N,d2

Emtricitabine-15N,d2  (Synonyms: BW1592-15N,d2)

Cat. No.: HY-17427S Purity: 97.64%
COA Handling Instructions

Molarity Calculator

Emtricitabine-15N,d2 is a 15N-labeled and deuterium labeled Emtricitabine. Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) with an EC50 of 0.01 μM in PBMC cell. It is an antiviral agent for the treatment of HIV infection.

For research use only. We do not sell to patients.

Emtricitabine-<sup>15</sup>N,d<sub>2</sub> Chemical Structure

Emtricitabine-15N,d2 Chemical Structure

CAS No. : 2714436-53-8

Size Price Stock Quantity
1 mg USD 380 In-stock
5 mg   Get quote  
10 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Emtricitabine-15N,d2:

Emtricitabine-15N,d2 Related Antibodies

Top Publications Citing Use of Products

View All HIV Isoform Specific Products:

View All Isoforms
HIV HIV-1 HIV-2

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Emtricitabine-15N,d2 is a 15N-labeled and deuterium labeled Emtricitabine. Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) with an EC50 of 0.01 μM in PBMC cell. It is an antiviral agent for the treatment of HIV infection.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Emtricitabine-15N,d2 Related Antibodies
Molecular Weight

250.25

Formula

C8H8D2FN215NO3S
CAS No.
Unlabeled CAS

143491-57-0
Appearance

Solid

Color

White to off-white

SMILES

O=C1N(C=C(C([15NH2])=N1)F)[C@@]2([H])O[C@H](SC2)C([2H])([2H])O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (399.60 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.9960 mL 19.9800 mL 39.9600 mL
5 mM 0.7992 mL 3.9960 mL 7.9920 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.9960 mL 19.9800 mL 39.9600 mL 99.9001 mL
5 mM 0.7992 mL 3.9960 mL 7.9920 mL 19.9800 mL
10 mM 0.3996 mL 1.9980 mL 3.9960 mL 9.9900 mL
15 mM 0.2664 mL 1.3320 mL 2.6640 mL 6.6600 mL
20 mM 0.1998 mL 0.9990 mL 1.9980 mL 4.9950 mL
25 mM 0.1598 mL 0.7992 mL 1.5984 mL 3.9960 mL
30 mM 0.1332 mL 0.6660 mL 1.3320 mL 3.3300 mL
40 mM 0.0999 mL 0.4995 mL 0.9990 mL 2.4975 mL
50 mM 0.0799 mL 0.3996 mL 0.7992 mL 1.9980 mL
60 mM 0.0666 mL 0.3330 mL 0.6660 mL 1.6650 mL
80 mM 0.0500 mL 0.2498 mL 0.4995 mL 1.2488 mL
100 mM 0.0400 mL 0.1998 mL 0.3996 mL 0.9990 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Emtricitabine-15N,d2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Emtricitabine-15N,d22714436-53-8BW1592-15N,d2HIVReverse TranscriptaseEndogenous MetaboliteHuman immunodeficiency virusInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Emtricitabine-15N,d2
Cat. No.:
HY-17427S
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.