Enalapril sodium (Synonyms: MK-421 sodium)

Cat. No.: HY-B0331B: FAQs
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Enalapril (MK-421) sodium is an angiotensin-converting enzyme (ACE) inhibitor, can be used for hypertensive diseases research.

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Enalapril sodium Chemical Structure

CAS No. : 149404-21-7

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Other In-stock Forms of Enalapril sodium:

Enalapril maleate

Other Forms of Enalapril sodium:

Enalapril maleate In-stock
Enalapril Get quote

7 Publications Citing Use of MCE Enalapril sodium

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Description

Enalapril (MK-421) sodium is an angiotensin-converting enzyme (ACE) inhibitor, can be used for hypertensive diseases research^[1]^[2].

In Vitro

Enalapril sodium (10-20 μM) has an antiarrhythmic effect in ultrafiltered PV sleeve preparation isolated from canine hearts which can inhibit EAD and DAD-induced activity^[1].
Enalapril sodium (50 μM, 24 hours) inhibits the induction of apoptosis by patient serum only when used prior to treatment of HUVEC with Alzheimer's disease (AD) serum^[2].
Pure Enalapril sodium has better thermal stability than pure Enalapril^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[2]

Cell Line:	Human umbilical vein ECs (HUVECs)
Concentration:	50 μM
Incubation Time:	24 hours
Result:	Inhibited the induction of apoptosis by patient serum.

In Vivo

Enalapril sodium (intraperitoneal injection, 0.03 mg/kg, once) reduces infarct volume due to middle cerebral artery occlusion and lower or higher doses are ineffective in Male NMRI mice^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male NMRI mice 20-40 g^[4]
Dosage:	0.03 mg/kg
Administration:	Intraperitoneal injection; once
Result:	Reduced the area of middle cerebral artery infarction in mice at 0.03 mg/kg.

Clinical Trial

Molecular Weight

398.43

Formula

C₂₀H₂₇N₂NaO₅

CAS No.

149404-21-7

SMILES

O=C(O[Na])[C@H]1N(C([C@H](C)N[C@H](C(OCC)=O)CCC2=CC=CC=C2)=O)CCC1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Serge Sicouri, et al. Antiarrhythmic effects of losartan and enalapril in canine pulmonary vein sleeve preparations. J Cardiovasc Electrophysiol. 2011 Jun;22(6):698-705. [Content Brief]

[2]. Rokhsareh Meamar, et al. Enalapril protects endothelial cells against induced apoptosis in Alzheimer's disease. J Res Med Sci. 2013 Mar;18(Suppl 1):S1-5. [Content Brief]

[3]. Talita A Cunha, et al. Effect of stearic acid on enalapril stability and dissolution from multiparticulate solid dosage forms. AAPS PharmSciTech. 2013 Sep;14(3):1150-7. [Content Brief]

[4]. A Ravati, et al. Enalapril and moexipril protect from free radical-induced neuronal damage in vitro and reduce ischemic brain injury in mice and rats. Eur J Pharmacol. 1999 May 28;373(1):21-33. [Content Brief]

Enalapril sodium Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Enalapril149404-21-7MK-421MK421MK 421Angiotensin-converting Enzyme (ACE)AntihypertensivesACE inhibitorInhibitorinhibitorinhibit

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