2. Metabolic Enzyme/Protease
  3. Angiotensin-converting Enzyme (ACE)
  4. Enalapril

Enalapril (MK-421) is an angiotensin-converting enzyme (ACE) inhibitor, can be used for hypertensive diseases research.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (Enalapril maleate) usually boasts enhanced water solubility and stability.

For research use only. We do not sell to patients.

Enalapril Chemical Structure

Enalapril Chemical Structure

CAS No. : 75847-73-3

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Enalapril Related Antibodies

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Description

Enalapril (MK-421) is an angiotensin-converting enzyme (ACE) inhibitor, can be used for hypertensive diseases research[1][2].

In Vitro

Enalapril (10-20 μM) has an antiarrhythmic effect in ultrafiltered PV sleeve preparation isolated from canine hearts which can inhibit EAD and DAD-induced activity[1].
Enalapril (50 μM, 24 hours) inhibits the induction of apoptosis by patient serum only when used prior to treatment of HUVEC with Alzheimer's disease (AD) serum[2].
Pure Enalapril has better thermal stability than pure Enalapril[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Enalapril Related Antibodies

Apoptosis Analysis[2]

Cell Line: Human umbilical vein ECs (HUVECs)
Concentration: 50 μM
Incubation Time: 24 hours
Result: Inhibited the induction of apoptosis by patient serum.
In Vivo

Enalapril (intraperitoneal injection, 0.03 mg/kg, once, 1 hour) reduces infarct volume due to middle cerebral artery occlusion and lower or higher doses are ineffective in Male NMRI mice[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male NMRI mice 20-40 g[4]
Dosage: 0.03 mg/kg
Administration: Intraperitoneal injection; once; 1 hour
Result: Reduced the area of middle cerebral artery infarction in mice at 0.03 mg/kg.
Clinical Trial
Molecular Weight

376.45

Formula

C20H28N2O5
CAS No.
SMILES

O=C(O)[C@H]1N(C([C@H](C)N[C@H](C(OCC)=O)CCC2=CC=CC=C2)=O)CCC1
Structure Classification
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Enalapril Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Enalapril75847-73-3MK-421MK421MK 421Angiotensin-converting Enzyme (ACE)AntihypertensivesACE inhibitorInhibitorinhibitorinhibit

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