Enalapril maleate (Synonyms: MK-421 maleate)

Name: Enalapril maleate
Brand: MedChemExpress
SKU: HY-B0331A
Rating: 5.0 (7 reviews)

Cat. No.: HY-B0331A Purity: 99.99%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Enalapril (MK-421) maleate, the active metabolite of enalapril, is an angiotensin-converting enzyme (ACE) inhibitor.

For research use only. We do not sell to patients.

Enalapril maleate Chemical Structure

CAS No. : 76095-16-4

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 33	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 33	In-stock	Estimated Time of Arrival: December 31
Solid
500 mg	USD 30	In-stock	Estimated Time of Arrival: December 31
1 g	USD 50	In-stock	Estimated Time of Arrival: December 31
5 g	USD 170	In-stock	Estimated Time of Arrival: December 31
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Based on 7 publication(s) in Google Scholar

Other Forms of Enalapril maleate:

7 Publications Citing Use of MCE Enalapril maleate

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Enalapril (MK-421) maleate, the active metabolite of enalapril, is an angiotensin-converting enzyme (ACE) inhibitor.

IC₅₀ & Target

ACE^[1].

In Vivo

Enalapril (MK-421) is a prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly metabolized in the liver to enalaprilat following oral administration. Enalapril (MK-421) is a potent, competitive inhibitor of ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Enalapril may be used to treat essential or renovascular hypertension and symptomatic congestive heart failure^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

Molecular Weight

492.52

Formula

C₂₄H₃₂N₂O₉

CAS No.

76095-16-4

Appearance

Solid

Color

White to off-white

SMILES

O=C(O)[C@H]1N(C([C@H](C)N[C@H](C(OCC)=O)CCC2=CC=CC=C2)=O)CCC1.O=C(O)/C=C\C(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : ≥ 50 mg/mL (101.52 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 33.33 mg/mL (67.67 mM; Need ultrasonic and warming)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.0304 mL	10.1519 mL	20.3037 mL
5 mM	0.4061 mL	2.0304 mL	4.0607 mL
10 mM	0.2030 mL	1.0152 mL	2.0304 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.99%

Select Batch:

Data Sheet (280 KB) SDS (393 KB)

COA (260 KB) HNMR (297 KB) LCMS (91 KB)

Handling Instructions (2659 KB)

References

[1]. Liu, Y.H., et al., Comparison of captopril and enalapril to study the role of the sulfhydryl-group in improvement of endothelial dysfunction with ACE inhibitors in high dieted methionine mice. J Cardiovasc Pharmacol, 2006. 47(1): p. 82-8. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	2.0304 mL	10.1519 mL	20.3037 mL	50.7594 mL
	5 mM	0.4061 mL	2.0304 mL	4.0607 mL	10.1519 mL
	10 mM	0.2030 mL	1.0152 mL	2.0304 mL	5.0759 mL
	15 mM	0.1354 mL	0.6768 mL	1.3536 mL	3.3840 mL
	20 mM	0.1015 mL	0.5076 mL	1.0152 mL	2.5380 mL
	25 mM	0.0812 mL	0.4061 mL	0.8121 mL	2.0304 mL
	30 mM	0.0677 mL	0.3384 mL	0.6768 mL	1.6920 mL
	40 mM	0.0508 mL	0.2538 mL	0.5076 mL	1.2690 mL
	50 mM	0.0406 mL	0.2030 mL	0.4061 mL	1.0152 mL
	60 mM	0.0338 mL	0.1692 mL	0.3384 mL	0.8460 mL
DMSO	80 mM	0.0254 mL	0.1269 mL	0.2538 mL	0.6345 mL
DMSO	100 mM	0.0203 mL	0.1015 mL	0.2030 mL	0.5076 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Enalapril maleate Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Enalapril76095-16-4MK-421MK421MK 421Angiotensin-converting Enzyme (ACE)Inhibitorinhibitorinhibit

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Enalapril maleate (Synonyms: MK-421 maleate)

Customer Review

Other Forms of Enalapril maleate:

Enalapril maleate Related Antibodies

7 Publications Citing Use of MCE Enalapril maleate

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity

Purity & Documentation

References

Customer Review

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Enalapril maleate Related Classifications

Keywords:

Your Recently Viewed Products:

Customer Review

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