2. GPCR/G Protein
  3. CaSR
  4. Encaleret

Encaleret (CLTX-305) is an orally active CaSR antagonist.

For research use only. We do not sell to patients.

Encaleret Chemical Structure

Encaleret Chemical Structure

CAS No. : 787583-71-5

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1 mg USD 160 In-stock
5 mg USD 400 In-stock
10 mg USD 650 In-stock
25 mg USD 1340 In-stock
50 mg USD 2150 In-stock
100 mg USD 3480 In-stock
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Based on 1 publication(s) in Google Scholar

Encaleret Related Antibodies

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Description

Encaleret (CLTX-305) is an orally active CaSR antagonist[1].

Molecular Weight

514.03

Formula

C29H33ClFNO4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC=C(C2=CC=CC=C2[C@H](OC[C@H](O)CNC(C)(C)CC3=CC=C(Cl)C(F)=C3)C)C=C1C)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 350 mg/mL (680.89 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9454 mL 9.7271 mL 19.4541 mL
5 mM 0.3891 mL 1.9454 mL 3.8908 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

Dosing volume
(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9454 mL 9.7271 mL 19.4541 mL 48.6353 mL
5 mM 0.3891 mL 1.9454 mL 3.8908 mL 9.7271 mL
10 mM 0.1945 mL 0.9727 mL 1.9454 mL 4.8635 mL
15 mM 0.1297 mL 0.6485 mL 1.2969 mL 3.2424 mL
20 mM 0.0973 mL 0.4864 mL 0.9727 mL 2.4318 mL
25 mM 0.0778 mL 0.3891 mL 0.7782 mL 1.9454 mL
30 mM 0.0648 mL 0.3242 mL 0.6485 mL 1.6212 mL
40 mM 0.0486 mL 0.2432 mL 0.4864 mL 1.2159 mL
50 mM 0.0389 mL 0.1945 mL 0.3891 mL 0.9727 mL
60 mM 0.0324 mL 0.1621 mL 0.3242 mL 0.8106 mL
80 mM 0.0243 mL 0.1216 mL 0.2432 mL 0.6079 mL
100 mM 0.0195 mL 0.0973 mL 0.1945 mL 0.4864 mL
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Encaleret Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Encaleret787583-71-5CLTX-305CLTX305CLTX 305CaSRCalcium-sensing receptorOralInhibitorinhibitorinhibit

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