Epolactaene

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Epolactaene is a potent Topoisomerase II and DNA Polymerase inhibitor with IC₅₀ values of 10, 25, 94 µM for Topoisomerase II, DNA Polymerase α, DNA Polymerase β, respectively.

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Epolactaene Chemical Structure

CAS No. : 167782-17-4

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Topoisomerase Topo I Topo II

Biological Activity
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Description

Epolactaene is a potent Topoisomerase II and DNA Polymerase inhibitor with IC₅₀ values of 10, 25, 94 µM for Topoisomerase II, DNA Polymerase α, DNA Polymerase β, respectively^[1].

IC₅₀ & Target^[1]

Topoisomerase II

10 μM (IC₅₀)

DNA Polymerase α

25 μM (IC₅₀)

DNA Polymerase β

94 μM (IC₅₀)

Cellular Effect

Cell Line	Type	Value	Description	References
BALL-1	IC₅₀	3.82 μM Compound: 1, Epolactaene	cytotoxicity against human BALL1 cells by MTT assay cytotoxicity against human BALL1 cells by MTT assay	[PMID: 18375133]
Jurkat	IC₅₀	1.5 μM Compound: Epo	inhibitory concentration against human T-lymphoma Jurkat cells (cell viability was assessed by MTT assay) inhibitory concentration against human T-lymphoma Jurkat cells (cell viability was assessed by MTT assay)	[PMID: 15357965]
SH-SY5Y	IC₅₀	3.9 μM Compound: Epo	inhibitory concentration against human neuroblastoma SH-SY5Y cells (cell viability was assessed by MTT assay) inhibitory concentration against human neuroblastoma SH-SY5Y cells (cell viability was assessed by MTT assay)	[PMID: 15357965]

Molecular Weight

389.44

Formula

C₂₁H₂₇NO₆

CAS No.

167782-17-4

SMILES

COC(C(/C=C(C)/C=C/CC/C=C(C)/C([C@@]12[C@@](C(O)(NC2=O)C)([H])O1)=O)=C/C)=O

Structure Classification

Others

Initial Source

Microorganisms

Penicillium sp.

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Mizushina Y, et al. Epolactaene, a novel neuritogenic compound in human neuroblastoma cells, selectively inhibits the activities of mammalian DNA polymerases and human DNA topoisomerase II. Biochem Biophys Res Commun. 2000 Jul 5;273(2):784-8. [Content Brief]

Epolactaene Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Epolactaene167782-17-4DNA/RNA SynthesisTopoisomeraseDNA PolymeraseTopoisomerase IIInhibitorinhibitorinhibit

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