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  4. EPZ033294

EPZ033294 is an inhibitor of SYMD2 (IC50 is 3.9 nM). SYMD2 itself has catalytic activity and can methylate the lysine residue of BTF3 to BTF3me1, which was experimentally demonstrated by detecting an IC50 of 2.9 nM for inhibition of BTF3ME1 by SYMD2, indicating an active inhibition of SYMD2 by EPZ033294. EPZ033294 (0-50 µM) has an inhibitory effect on SYMD2 and a concentration-dependent inhibitory effect in 293T.

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EPZ033294 Chemical Structure

EPZ033294 Chemical Structure

CAS No. : 1887195-17-6

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EPZ033294 Related Antibodies

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Description

EPZ033294 is an inhibitor of SYMD2 (IC50 is 3.9 nM). SYMD2 itself has catalytic activity and can methylate the lysine residue of BTF3 to BTF3me1, which was experimentally demonstrated by detecting an IC50 of 2.9 nM for inhibition of BTF3ME1 by SYMD2, indicating an active inhibition of SYMD2 by EPZ033294. EPZ033294 (0-50 µM) has an inhibitory effect on SYMD2 and a concentration-dependent inhibitory effect in 293T[1].

IC50 & Target

SYMD2 [1]
In Vitro

EPZ033294 (0-50 µM) has an inhibitory effect on SMYD2 and a concentration-dependent inhibitory effect in 293T [2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

EPZ033294 Related Antibodies

Western Blot Analysis[1]

Cell Line: 293T
Concentration: 0, 3.12, 6.25, 12.5, 25 and 50 µM
Incubation Time: 1000 s
Result: Inhibited SMYD2.
Molecular Weight

411.89

Formula

C20H22ClN7O
CAS No.
SMILES

O=C(C1=CN(C2CC2)N=N1)NC3CN(C3)CC4=CN(CC5=CC=C(C=C5)Cl)N=C4
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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EPZ033294 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EPZ0332941887195-17-6EPZ 033294EPZ-033294OthersNon-competitive ligandSMYD2 inhibitorMethylation inhibitorInhibitorinhibitorinhibit

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