Ermanin

Cat. No.: HY-N3848: FAQs
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Ermanin is a flavonoid isolated from Tanacetum microphyllum. Ermanin potently inhibits iNOS, COX-2 activities, and inhibits platelet aggregation. Ermanin has anti-inflammatory, anti-tuberculous and anti-viral/bacterial properties.

For research use only. We do not sell to patients.

Ermanin Chemical Structure

CAS No. : 20869-95-8

Size	Stock
5 mg	Get quote	Estimated Time of Arrival: December 31
10 mg	Get quote	Estimated Time of Arrival: December 31
25 mg	Get quote	Estimated Time of Arrival: December 31

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This product is a controlled substance and not for sale in your territory.

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COX COX-1 COX-2 COX-3

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nNOS iNOS eNOS

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

iNOS

Bacterial

COX-2

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	3.1 x 10^-5 M Compound: 25	Cytotoxicity against human A549 cells after 72 hrs by XTT assay Cytotoxicity against human A549 cells after 72 hrs by XTT assay	[PMID: 20619940]
HeLa	IC₅₀	3.1 x 10^-5 M Compound: 25	Cytotoxicity against human HeLa cells after 72 hrs by XTT assay Cytotoxicity against human HeLa cells after 72 hrs by XTT assay	[PMID: 20619940]
HT-1080	ED₅₀	< 8 μg/mL Compound: Ermanin	Cytotoxicity against human HT1080 cells by MTT assay Cytotoxicity against human HT1080 cells by MTT assay	[PMID: 11000036]
HT-1080	ED₅₀	2.3 μg/mL Compound: 21	Cytotoxicity against human HT1080 cells after 24 hrs by MTT assay Cytotoxicity against human HT1080 cells after 24 hrs by MTT assay	[PMID: 9677271]
HT-29	IC₅₀	3.2 x 10^-5 M Compound: 25	Cytotoxicity against human HT-29 cells after 72 hrs by XTT assay Cytotoxicity against human HT-29 cells after 72 hrs by XTT assay	[PMID: 20619940]

Molecular Weight

314.29

Formula

C₁₇H₁₄O₆

CAS No.

20869-95-8

SMILES

O=C1C(OC)=C(C2=CC=C(OC)C=C2)OC3=CC(O)=CC(O)=C13

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Sandeep Appunni, et al. Targeting PknB, an Eukaryotic-Like serine/threonine Protein Kinase of Mycobacterium Tuberculosis With Phytomolecules. Comput Biol Chem. 2017 Apr;67:200-204. [Content Brief]

[2]. Jih-Jung Chen, et al. New Sesquiterpenoids and Anti-Platelet Aggregation Constituents From the Rhizomes of Curcuma Zedoaria. Molecules. 2016 Oct 17;21(10):1385. [Content Brief]

Ermanin Related Classifications

Inflammation/Immunology Infection Cardiovascular Disease

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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