2. Others Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  3. Isotope-Labeled Compounds Estrogen Receptor/ERR Endogenous Metabolite
  4. Estriol-d3

Estriol-d3 is the deuterium labeled Estriol. Estriol is an antagonist of the G-protein coupled estrogen receptor in estrogen receptor-negative breast cancer cells.

For research use only. We do not sell to patients.

Estriol-d<sub>3</sub> Chemical Structure

Estriol-d3 Chemical Structure

CAS No. : 79037-36-8

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Based on 1 publication(s) in Google Scholar

Other Forms of Estriol-d3:

Estriol-d3 Related Antibodies

Top Publications Citing Use of Products

View All Estrogen Receptor/ERR Isoform Specific Products:

View All Isoforms
Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Estriol-d3 is the deuterium labeled Estriol. Estriol is an antagonist of the G-protein coupled estrogen receptor in estrogen receptor-negative breast cancer cells.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Estriol-d3 Related Antibodies
Molecular Weight

291.40

Formula

C18H21D3O3
CAS No.
Unlabeled CAS

50-27-1
Appearance

Solid

Color

White to off-white

SMILES

C[C@@]12[C@](C[C@H]([C@]2([2H])O)O)([H])[C@@]3([H])[C@@](CC1)([H])C4=CC([2H])=C(O)C([2H])=C4CC3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (857.93 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMSO : 250 mg/mL (857.93 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 0.1 mg/mL (0.34 mM; ultrasonic and warming and heat to 80°C)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4317 mL 17.1585 mL 34.3171 mL
5 mM 0.6863 mL 3.4317 mL 6.8634 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 97.57%

COA (251 KB) HNMR (774 KB) RP-HPLC (988 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / DMSO 1 mM 3.4317 mL 17.1585 mL 34.3171 mL 85.7927 mL
5 mM 0.6863 mL 3.4317 mL 6.8634 mL 17.1585 mL
10 mM 0.3432 mL 1.7159 mL 3.4317 mL 8.5793 mL
15 mM 0.2288 mL 1.1439 mL 2.2878 mL 5.7195 mL
20 mM 0.1716 mL 0.8579 mL 1.7159 mL 4.2896 mL
25 mM 0.1373 mL 0.6863 mL 1.3727 mL 3.4317 mL
30 mM 0.1144 mL 0.5720 mL 1.1439 mL 2.8598 mL
40 mM 0.0858 mL 0.4290 mL 0.8579 mL 2.1448 mL
50 mM 0.0686 mL 0.3432 mL 0.6863 mL 1.7159 mL
60 mM 0.0572 mL 0.2860 mL 0.5720 mL 1.4299 mL
80 mM 0.0429 mL 0.2145 mL 0.4290 mL 1.0724 mL
100 mM 0.0343 mL 0.1716 mL 0.3432 mL 0.8579 mL
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Estriol-d3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Estriol-d379037-36-8Isotope-Labeled CompoundsEstrogen Receptor/ERREndogenous MetaboliteInhibitorinhibitorinhibit

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