Estrone sulfate-d₄ sodium

Name: Estrone sulfate-d 4 sodium
Brand: MedChemExpress
SKU: HY-113293BS1
Rating: 4.5 (1 reviews)

Cat. No.: HY-113293BS1 Purity: 99.38%: FAQs
Data Sheet SDS COA Handling Instructions

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Estrone sulfate-d₄ (sodium) is deuterium labeled Estrone sulfate (sodium). Estrone sulfate, a biologically inactive form of estrogen, is a major circulating plasma estrogen that is converted into the biologically active estrogen, estrone (E1) by steroid sulfatase (STS). strone sulfate can be used for the research of breast cancer[1][2].

For research use only. We do not sell to patients.

Estrone sulfate-d<sub>4</sub> sodium Chemical Structure

Estrone sulfate-d₄ sodium Chemical Structure

CAS No. : 285979-80-8

Size	Price	Stock	Quantity
1 mg	USD 55	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 200	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 320	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of Estrone sulfate-d₄ sodium:

Estrone sulfate sodium Get quote

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•Related Small Molecules:

•Related Proteins:

View All Estrogen Receptor/ERR Isoform Specific Products:

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Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

376.44

Formula

C₁₈H₁₇D₄NaO₅S

CAS No.

285979-80-8

Unlabeled CAS

438-67-5

Appearance

Solid

Color

White to off-white

SMILES

[2H]C1=C(OS(=O)(O[Na])=O)C([2H])=C(CC[C@]2([H])[C@]3([H])CC[C@@]4(C)[C@@]2([H])CC([2H])([2H])C4=O)C3=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 25 mg/mL (66.41 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6565 mL	13.2823 mL	26.5647 mL
5 mM	0.5313 mL	2.6565 mL	5.3129 mL
10 mM	0.2656 mL	1.3282 mL	2.6565 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Dosing volume
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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.38%

Select Batch:

Data Sheet (275 KB) SDS (419 KB)

COA (252 KB) HNMR (264 KB) RP-HPLC (280 KB) LCMS (98 KB)

Handling Instructions (2659 KB)

References

[1]. Duncan L, et al. Inhibition of estrone sulfatase activity by estrone-3-methylthiophosphonate: a potential therapeutic agent in breast cancer. Cancer Res. 1993;53(2):298-303. [Content Brief]

[2]. Karakus E, et al. Estrone-3-Sulfate Stimulates the Proliferation of T47D Breast Cancer Cells Stably Transfected With the Sodium-Dependent Organic Anion Transporter SOAT (SLC10A6). Front Pharmacol. 2018;9:941. Published 2018 Aug 21. [Content Brief]

[3]. Nakamura Y, et al. Steroid sulfatase and estrogen sulfotransferase in the atherosclerotic human aorta. Am J Pathol. 2003;163(4):1329-1339. [Content Brief]

[4]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.6565 mL	13.2823 mL	26.5647 mL	66.4116 mL
	5 mM	0.5313 mL	2.6565 mL	5.3129 mL	13.2823 mL
	10 mM	0.2656 mL	1.3282 mL	2.6565 mL	6.6412 mL
	15 mM	0.1771 mL	0.8855 mL	1.7710 mL	4.4274 mL
	20 mM	0.1328 mL	0.6641 mL	1.3282 mL	3.3206 mL
	25 mM	0.1063 mL	0.5313 mL	1.0626 mL	2.6565 mL
	30 mM	0.0885 mL	0.4427 mL	0.8855 mL	2.2137 mL
	40 mM	0.0664 mL	0.3321 mL	0.6641 mL	1.6603 mL
	50 mM	0.0531 mL	0.2656 mL	0.5313 mL	1.3282 mL
	60 mM	0.0443 mL	0.2214 mL	0.4427 mL	1.1069 mL