2. Metabolic Enzyme/Protease
  3. Pyruvate Kinase
  4. Etavopivat

Etavopivat  (Synonyms: FT-4202)

Cat. No.: HY-139573 Purity: 98.70%
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Etavopivat is a potent, selective, and orally active erythrocyte pyruvate kinase (PKR) activator. Etavopivat has potent antisickling effects that can be used in studies of sickle cell disease and other haemoglobinopathies.

For research use only. We do not sell to patients.

Etavopivat Chemical Structure

Etavopivat Chemical Structure

CAS No. : 2245053-57-8

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 544 In-stock
Solution
10 mM * 1 mL in DMSO USD 544 In-stock
Solid
5 mg USD 540 In-stock
10 mg USD 950 In-stock
25 mg USD 1950 In-stock
50 mg USD 3350 In-stock
100 mg USD 5800 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

Other Forms of Etavopivat:

Etavopivat Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Etavopivat is a potent, selective, and orally active erythrocyte pyruvate kinase (PKR) activator. Etavopivat has potent antisickling effects that can be used in studies of sickle cell disease and other haemoglobinopathies[1][2].

In Vitro

Etavopivat (20 μM, 4 h) improves haemoglobin-oxygen affinity and reduces the sickle point (PoS) in human red blood cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Etavopivat Related Antibodies
In Vivo

Etavopivat (500-1000 mg/kg, p.o., daily, 2 weeks) improves RBC survival and Hb levels in SCA mice[1].
Etavopivat (3-22 mg/kg, p.o., daily, 5 days) causes an increase in 2,3-DPG and ATP in crab-eating monkeys at doses of 8 mg/kg and 22 mg/kg[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SCA mice[1]
Dosage: 500-1000 mg/kg
Administration: p.o., daily, 2 weeks
Result: Decreased the levels of 2,3-DPG.
Increased ATP levels.
Reduced sickling in vivo.
Clinical Trial
Molecular Weight

457.50

Formula

C22H23N3O6S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=S(N1CC2=C(CN(C2)C([C@@H](C3=CC=CC=C3)CO)=O)C1)(C4=CN=C(OCCO5)C5=C4)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (109.29 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1858 mL 10.9290 mL 21.8579 mL
5 mM 0.4372 mL 2.1858 mL 4.3716 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1858 mL 10.9290 mL 21.8579 mL 54.6448 mL
5 mM 0.4372 mL 2.1858 mL 4.3716 mL 10.9290 mL
10 mM 0.2186 mL 1.0929 mL 2.1858 mL 5.4645 mL
15 mM 0.1457 mL 0.7286 mL 1.4572 mL 3.6430 mL
20 mM 0.1093 mL 0.5464 mL 1.0929 mL 2.7322 mL
25 mM 0.0874 mL 0.4372 mL 0.8743 mL 2.1858 mL
30 mM 0.0729 mL 0.3643 mL 0.7286 mL 1.8215 mL
40 mM 0.0546 mL 0.2732 mL 0.5464 mL 1.3661 mL
50 mM 0.0437 mL 0.2186 mL 0.4372 mL 1.0929 mL
60 mM 0.0364 mL 0.1821 mL 0.3643 mL 0.9107 mL
80 mM 0.0273 mL 0.1366 mL 0.2732 mL 0.6831 mL
100 mM 0.0219 mL 0.1093 mL 0.2186 mL 0.5464 mL
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Etavopivat Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Etavopivat2245053-57-8FT-4202FT4202FT 4202Pyruvate Kinaseorally activeantisicklingerythrocytehaemoglobinopathiesInhibitorinhibitorinhibit

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