Ethyl 7-(diethylamino)-2-oxo-2H-chromene-3-carboxylate

Cat. No.: HY-W087433 Purity: 99.78%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

Ethyl 7-(diethylamino)-2-oxo-2H-chromene-3-carboxylate is a potent and selective inhibitor of hMAO-B with an IC₅₀ of 45.52 μM.

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Ethyl 7-(diethylamino)-2-oxo-2H-chromene-3-carboxylate Chemical Structure

CAS No. : 28705-46-6

Size	Stock	Quantity

Free Sample (0.1 - 0.5 mg)	Apply Now
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
250 mg	In-stock	Estimated Time of Arrival: December 31
1 g	In-stock	Estimated Time of Arrival: December 31
5 g	Get quote
10 g	Get quote

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MAO-A MAO-B

Biological Activity
Purity & Documentation
References
Customer Review

Description

Ethyl 7-(diethylamino)-2-oxo-2H-chromene-3-carboxylate is a potent and selective inhibitor of hMAO-B with an IC₅₀ of 45.52 μM^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
BTI-TN-5B1-4	IC₅₀	45.52 μM Compound: 32	Inhibition of human recombinant MAO-B expressed in baculovirus infected BTI-TN-5B1-4 cells assessed as production of hydrogen peroxide from p-tyramine after 15 mins by microplate fluorescence assay Inhibition of human recombinant MAO-B expressed in baculovirus infected BTI-TN-5B1-4 cells assessed as production of hydrogen peroxide from p-tyramine after 15 mins by microplate fluorescence assay	[PMID: 21872365]
LOX IMVI	IC₅₀	> 10 μM Compound: 5	Cytotoxicity against human LOXIMVI cells after 96 hrs by Alamar blue method Cytotoxicity against human LOXIMVI cells after 96 hrs by Alamar blue method	[PMID: 18280154]
OVCAR-5	IC₅₀	> 10 μM Compound: 5	Cytotoxicity against human OVCAR5 cells after 96 hrs by Alamar blue method Cytotoxicity against human OVCAR5 cells after 96 hrs by Alamar blue method	[PMID: 18280154]

Molecular Weight

289.33

Formula

C₁₆H₁₉NO₄

CAS No.

28705-46-6

Appearance

Solid

Color

Light green to green

SMILES

O=C(C1=CC2=CC=C(N(CC)CC)C=C2OC1=O)OCC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (172.81 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.4563 mL	17.2813 mL	34.5626 mL
5 mM	0.6913 mL	3.4563 mL	6.9125 mL
10 mM	0.3456 mL	1.7281 mL	3.4563 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.78%

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Data Sheet (268 KB) SDS (393 KB)

COA (247 KB) HNMR (113 KB) RP-HPLC (189 KB)

Handling Instructions (2659 KB)

References

[1]. Secci D, et al. Synthesis and selective human monoamine oxidase inhibition of 3-carbonyl, 3-acyl, and 3-carboxyhydrazido coumarin derivatives. Eur J Med Chem. 2011 Oct;46(10):4846-52. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.4563 mL	17.2813 mL	34.5626 mL	86.4065 mL
	5 mM	0.6913 mL	3.4563 mL	6.9125 mL	17.2813 mL
	10 mM	0.3456 mL	1.7281 mL	3.4563 mL	8.6407 mL
	15 mM	0.2304 mL	1.1521 mL	2.3042 mL	5.7604 mL
	20 mM	0.1728 mL	0.8641 mL	1.7281 mL	4.3203 mL
	25 mM	0.1383 mL	0.6913 mL	1.3825 mL	3.4563 mL
	30 mM	0.1152 mL	0.5760 mL	1.1521 mL	2.8802 mL
	40 mM	0.0864 mL	0.4320 mL	0.8641 mL	2.1602 mL
	50 mM	0.0691 mL	0.3456 mL	0.6913 mL	1.7281 mL
	60 mM	0.0576 mL	0.2880 mL	0.5760 mL	1.4401 mL
	80 mM	0.0432 mL	0.2160 mL	0.4320 mL	1.0801 mL
	100 mM	0.0346 mL	0.1728 mL	0.3456 mL	0.8641 mL