Ethyl β-carboline-3-carboxylate

Cat. No.: HY-137494 Purity: 99.75%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

Ethyl β-carboline-3-carboxylate (fl-CCE) is a ligand and short-acting antagonist of benzodiazepine receptors. Ethyl β-carboline-3-carboxylate did not affect cerebellar cGMP levels when used alone, but when taken together with Diazepam, it significantly inhibited the cGMP levels that were upregulated by Diazepam.

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Ethyl β-carboline-3-carboxylate Chemical Structure

CAS No. : 74214-62-3

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

Benzodiazepine receptor^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
769-P	IC₅₀	175 μM Compound: 4	Cytotoxicity against human renal carcinoma 769-P cells assessed as reduction in optical density by MTT assay Cytotoxicity against human renal carcinoma 769-P cells assessed as reduction in optical density by MTT assay	[PMID: 23279863]
A-375	IC₅₀	> 200 μM Compound: 4	Cytotoxicity against human malignant melanoma A375 cells assessed as reduction in optical density by MTT assay Cytotoxicity against human malignant melanoma A375 cells assessed as reduction in optical density by MTT assay	[PMID: 23279863]
BGC-823	IC₅₀	> 200 μM Compound: 4	Cytotoxicity against human gastric carcinoma BGC823 cells assessed as reduction in optical density by MTT assay Cytotoxicity against human gastric carcinoma BGC823 cells assessed as reduction in optical density by MTT assay	[PMID: 23279863]
KB	IC₅₀	> 200 μM Compound: 4	Cytotoxicity against human epidermoid carcinoma of the nasopharynx KB cells assessed as reduction in optical density by MTT assay Cytotoxicity against human epidermoid carcinoma of the nasopharynx KB cells assessed as reduction in optical density by MTT assay	[PMID: 23279863]
SK-OV-3	IC₅₀	92.6 μM Compound: 4	Cytotoxicity against human ovary adenocarcinoma SKOV3 cells assessed as reduction in optical density by MTT assay Cytotoxicity against human ovary adenocarcinoma SKOV3 cells assessed as reduction in optical density by MTT assay	[PMID: 23279863]

Molecular Weight

240.26

Formula

C₁₄H₁₂N₂O₂

CAS No.

74214-62-3

Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(C1=CC2=C(C=N1)NC3=C2C=CC=C3)OCC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (208.11 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.1622 mL	20.8108 mL	41.6216 mL
5 mM	0.8324 mL	4.1622 mL	8.3243 mL
10 mM	0.4162 mL	2.0811 mL	4.1622 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.75%

Select Batch:

Data Sheet (272 KB) SDS (393 KB)

COA (252 KB) HNMR (247 KB) LCMS (97 KB)

Handling Instructions (2659 KB)

References

[1]. ETHYL-CARBOLINE-3-CARBOXYLATE REVERSES THE DIAZEPAM EFFECT ON CEREBELLAR CYCLIC GMP

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.1622 mL	20.8108 mL	41.6216 mL	104.0539 mL
	5 mM	0.8324 mL	4.1622 mL	8.3243 mL	20.8108 mL
	10 mM	0.4162 mL	2.0811 mL	4.1622 mL	10.4054 mL
	15 mM	0.2775 mL	1.3874 mL	2.7748 mL	6.9369 mL
	20 mM	0.2081 mL	1.0405 mL	2.0811 mL	5.2027 mL
	25 mM	0.1665 mL	0.8324 mL	1.6649 mL	4.1622 mL
	30 mM	0.1387 mL	0.6937 mL	1.3874 mL	3.4685 mL
	40 mM	0.1041 mL	0.5203 mL	1.0405 mL	2.6013 mL
	50 mM	0.0832 mL	0.4162 mL	0.8324 mL	2.0811 mL
	60 mM	0.0694 mL	0.3468 mL	0.6937 mL	1.7342 mL
	80 mM	0.0520 mL	0.2601 mL	0.5203 mL	1.3007 mL
	100 mM	0.0416 mL	0.2081 mL	0.4162 mL	1.0405 mL