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  4. Ethylenediaminetetraacetic acid sodium hydrate

Ethylenediaminetetraacetic acid sodium hydrate  (Synonyms: EDTA sodium hydrate)

Cat. No.: HY-W105700 Purity: ≥98.0%
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Ethylenediaminetetraacetic acid (EDTA) sodium hydrate is a kind of metal chelating agent (binds to bivalent and trivalent metal cations, including calcium). Ethylenediaminetetraacetic acid sodium hydrate has antibacterial, anti-inflammatory, antioxidant, anti-hypercalcemia and anticoagulant activities. Ethylenediaminetetraacetic acid sodium hydrate decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid sodium hydrate can alleviate the liver fibrosis. Ethylenediaminetetraacetic acid sodium hydrate can be used for coronary artery disease and neural system disease research.

For research use only. We do not sell to patients.

Ethylenediaminetetraacetic acid sodium hydrate Chemical Structure

Ethylenediaminetetraacetic acid sodium hydrate Chemical Structure

CAS No. : 10378-23-1

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Ethylenediaminetetraacetic acid sodium hydrate Related Antibodies

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Description

Ethylenediaminetetraacetic acid (EDTA) sodium hydrate is a kind of metal chelating agent (binds to bivalent and trivalent metal cations, including calcium). Ethylenediaminetetraacetic acid sodium hydrate has antibacterial, anti-inflammatory, antioxidant, anti-hypercalcemia and anticoagulant activities. Ethylenediaminetetraacetic acid sodium hydrate decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid sodium hydrate can alleviate the liver fibrosis. Ethylenediaminetetraacetic acid sodium hydrate can be used for coronary artery disease and neural system disease research[1][2][3][4][5][6][7].

In Vitro

Ethylenediaminetetraacetic acid has a strong bactericidal effect on the cell wall of P. aeruginosa and a. faecalis[4].
Ethylenediaminetetraacetic acid (0.005-0.01 M) has good heavy metal extraction in contaminated silty-clay-loam soil columns, can extract Pb, Cd and Zn in a concentration-dependent way with an extraction efficiency sequence of Pb > Cd > Zn[6].
Ethylenediaminetetraacetic acid (1.2 mM) enhances the activity of the CRE driving promoter by activating T-cell death-associated gene 8 (TDAG8) in HEK293T cells, thereby enhancing the production of cAMP in the cells[7].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ethylenediaminetetraacetic acid sodium hydrate Related Antibodies
In Vivo

Ethylenediaminetetraacetic acid (60 mg/kg; Intraperitoneal injection; Three times per week for three weeks) can reduce liver fibrosis, lipid peroxidation and liver inflammation in CCl4 induced liver fibrosis rats, and has antioxidant and anti-inflammatory activities[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rat model of cirrhosis induced by CCl4[5]
Dosage: 60 mg/kg, 120 mg/kg, 240 mg/kg
Administration: Intraperitoneal injection (i.p.); Three times per week for 3 weeks (during this period, CCl4 administration continued). After CCl4 and mineral oil mixture treatment (200 μL/mouse; i.p.; Three times per week for eight weeks).
Result: Kept kept all the rats alive at the 60 mg/kg dose, but died at 120 and 240 mg/kg.
Reduced fibrosis of the liver in surviving rats (20%).
Animal Model: Male Wistar rat model of cirrhosis induced by CCl[5]
Dosage: 60 mg/kg
Administration: Intraperitoneal injection (i.p.); Three times per week for 11 weeks. (Preventive Ethylenediaminetetraacetic acid (EDTA) group: EDTA and CCl4 were administered during 11 weeks, three times per week on alternate days).
Intraperitoneal injection (i.p.); Three times per week. After CCl4 treatment (i.p.; Three times per week for eight weeks) (Therapeutic EDTA group: EDTA and CCl4 were administered for 3 weeks, three times per week on alternate days).
Result: Increased sod activity by 50% in the preventive EDTA group. (Compared with untreated EDTA group)
Increased Cp activity in the preventive EDTA (30%) and therapeutic EDTA (20%) groups. (Compared with the fibrotic group)
Decreased mRNA expression of the pro-inflammatory molecule (TNF-α and LI-6) and the profibrogenic molecules (TGF-β and αCOLI) in both the prevention and treatment groups.
Clinical Trial
Molecular Weight

416.20

Formula

C10H16N2Na4O10
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[Na].O=C(O)CN(CC(=O)O)CCN(CC(=O)O)CC(=O)O.O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Store at room temperature 3 years

In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

H2O : ≥ 100 mg/mL (240.27 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4027 mL 12.0135 mL 24.0269 mL
5 mM 0.4805 mL 2.4027 mL 4.8054 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.4027 mL 12.0135 mL 24.0269 mL 60.0673 mL
5 mM 0.4805 mL 2.4027 mL 4.8054 mL 12.0135 mL
10 mM 0.2403 mL 1.2013 mL 2.4027 mL 6.0067 mL
15 mM 0.1602 mL 0.8009 mL 1.6018 mL 4.0045 mL
20 mM 0.1201 mL 0.6007 mL 1.2013 mL 3.0034 mL
25 mM 0.0961 mL 0.4805 mL 0.9611 mL 2.4027 mL
30 mM 0.0801 mL 0.4004 mL 0.8009 mL 2.0022 mL
40 mM 0.0601 mL 0.3003 mL 0.6007 mL 1.5017 mL
50 mM 0.0481 mL 0.2403 mL 0.4805 mL 1.2013 mL
60 mM 0.0400 mL 0.2002 mL 0.4004 mL 1.0011 mL
80 mM 0.0300 mL 0.1502 mL 0.3003 mL 0.7508 mL
100 mM 0.0240 mL 0.1201 mL 0.2403 mL 0.6007 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Ethylenediaminetetraacetic acid sodium hydrate Related Classifications

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ethylenediaminetetraacetic acid sodium10378-23-1EDTA sodiumBiochemical Assay ReagentsBacterialSODSuperoxide DismutaseAnticoagulantAnti-hypercalcemicProtein purificationProtein storageHEK293TTDAG8cAMPChelating agentHypercalcemiaHepatic fibrosisInhibitorinhibitorinhibit

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