Etoxadrol (Synonyms: NSC 288020; CL-1848C)

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Etoxadrol (CL-1848C) is a potent, high-affinity N-methyl-D-aspartic acid (NMDA) antagonist. Etoxadrol is used in the anaesthetic and anaesthesia research community to suppress or relieve pain.

For research use only. We do not sell to patients.

Etoxadrol Chemical Structure

CAS No. : 28189-85-7

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Description

Etoxadrol (CL-1848C) is a potent, high-affinity N-methyl-D-aspartic acid (NMDA) antagonist. Etoxadrol is used in the anaesthetic and anaesthesia research community to suppress or relieve pain^[1].

IC₅₀ & Target

NMDA^[1]

In Vivo

Etoxadrol (CL-1848C) (100.0 mg/kg; i.h.; once) produces marked stimulation and ataxia in mice^[2].
Etoxadrol (0-20 mg/kg; i.v.; once) decreases brain monoamine concentrations after 4 h injection^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Carworth-Farm (Upjohn) male mice weighing 18 to 20 gm^[2]
Dosage:	100.0 mg/kg
Administration:	Subcutaneous injection, 30 min
Result:	Produced marked stimulation and ataxia.

Animal Model:	Male CFE rats weighing 110-175 g (average 130 g)^[3]
Dosage:	5, 10, and 20 mg/kg
Administration:	Intravenous injection, once
Result:	Significantly lowered brain serotonin, DA (dopamine), and NE (norepinephrine) concentrations at 4 h.

Molecular Weight

261.36

Formula

C₁₆H₂₃NO₂

CAS No.

28189-85-7

SMILES

CC[C@@]1(C2=CC=CC=C2)O[C@]([C@]3([H])CCCCN3)([H])CO1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. A Thurkauf, et al. Synthesis, absolute configuration, and molecular modeling study of etoxadrol, a potent phencyclidine-like agonist. J Med Chem. 1988 Dec;31(12):2257-63. [Content Brief]

[2]. A H Tang, et al. Analgetic activities of etoxadrol in the rhesus monkey and in mice. Anesth Analg. 1973 Jul-Aug;52(4):577-83. [Content Brief]

[3]. Y F Sung, et al. Effects of intravenous anesthetics on brain monoamines in the rat. Anesthesiology. 1973 Nov;39(5):478-87. [Content Brief]

Etoxadrol Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Etoxadrol28189-85-7NSC 288020 CL-1848CNSC288020NSC-288020OthersHigh affinityInhibitorinhibitorinhibit

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