2. Autophagy
  3. Autophagy
  4. Euxanthone

Euxanthone, a xanthone derivative, attenuates Aβ1-42-induced oxidative stress and apoptosis by triggering autophagy. Euxanthone exhibits anti-neoplastic and neuroprotective activities.

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Euxanthone Chemical Structure

Euxanthone Chemical Structure

CAS No. : 529-61-3

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Based on 1 publication(s) in Google Scholar

Euxanthone Related Antibodies

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Description

Euxanthone, a xanthone derivative, attenuates Aβ1-42-induced oxidative stress and apoptosis by triggering autophagy. Euxanthone exhibits anti-neoplastic and neuroprotective activities[1][2][3].

Cellular Effect
Cell Line Type Value Description References
A549 IC50
> 200 μM
Compound: 8
Cytotoxicity against Taxol-resistant human A549 cells measured after 48 hrs by MTT assay
Cytotoxicity against Taxol-resistant human A549 cells measured after 48 hrs by MTT assay
[PMID: 28065566]
A549 IC50
14.5 mg/mL
Compound: 13
Cytotoxicity against human A549 cells after 3 days by SRB assay
Cytotoxicity against human A549 cells after 3 days by SRB assay
[PMID: 15568778]
HeLa S3 IC50
> 10 μM
Compound: 19
Cytotoxicity in human HeLaS3 cells incubated for 72 hrs by MTT assay
Cytotoxicity in human HeLaS3 cells incubated for 72 hrs by MTT assay
[PMID: 30978023]
HepG2 IC50
> 10 μM
Compound: 19
Cytotoxicity in human HepG2 cells incubated for 72 hrs by MTT assay
Cytotoxicity in human HepG2 cells incubated for 72 hrs by MTT assay
[PMID: 30978023]
HT-29 IC50
> 10 μM
Compound: 19
Cytotoxicity in human HT-29 cells incubated for 72 hrs by MTT assay
Cytotoxicity in human HT-29 cells incubated for 72 hrs by MTT assay
[PMID: 30978023]
KB IC50
> 10 μM
Compound: 19
Cytotoxicity in human KB cells incubated for 72 hrs by MTT assay
Cytotoxicity in human KB cells incubated for 72 hrs by MTT assay
[PMID: 30978023]
MCF7 IC50
> 10 μM
Compound: 19
Cytotoxicity in human MCF7 cells incubated for 72 hrs by MTT assay
Cytotoxicity in human MCF7 cells incubated for 72 hrs by MTT assay
[PMID: 30978023]
MCF7 IC50
19.5 mg/mL
Compound: 13
Cytotoxicity against human MCF7 cells after 3 days by SRB assay
Cytotoxicity against human MCF7 cells after 3 days by SRB assay
[PMID: 15568778]
NCI/ADR-RES IC50
> 200 μM
Compound: 8
Cytotoxicity against human MCF7/ADR cells measured after 48 hrs by MTT assay
Cytotoxicity against human MCF7/ADR cells measured after 48 hrs by MTT assay
[PMID: 28065566]
OVCAR-3 IC50
> 10 μM
Compound: 27
Antiproliferative activity against human OVCAR3 cells assessed as reduction in cell viability after 48 hrs by CCK8 assay
Antiproliferative activity against human OVCAR3 cells assessed as reduction in cell viability after 48 hrs by CCK8 assay
[PMID: 30830783]
SK-OV-3 IC50
> 10 μM
Compound: 27
Antiproliferative activity against human SKOV3 cells assessed as reduction in cell viability after 48 hrs by CCK8 assay
Antiproliferative activity against human SKOV3 cells assessed as reduction in cell viability after 48 hrs by CCK8 assay
[PMID: 30830783]
SMMC-7721 IC50
60.35 μM
Compound: 8
Cytotoxicity against Taxol-resistant human SMMC7721 cells measured after 48 hrs by MTT assay
Cytotoxicity against Taxol-resistant human SMMC7721 cells measured after 48 hrs by MTT assay
[PMID: 28065566]
In Vitro

Euxanthone (10-20 μM; 24 h) compromises the capability of OS cells to migrate in a dose-dependent fashion, and significantly suppresses cell invasion. Euxanthone presents a significant decrease in adhesion to fibronectin[1].
Euxanthone (10-20 μM; 24 h) modulates the COX-2 expression through the miR-21/PDCD4/c-jun signaling pathway. The repression of COX-2 by Euxanthone mediated its anti-metastatic activities[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Euxanthone Related Antibodies

Cell Migration Assay [1]

Cell Line: Osteosarcoma (OS) cells
Concentration: 10 μM, 20 μM
Incubation Time: 24 h
Result: Inhibited cell migration at 24 hr.

Western Blot Analysis[1]

Cell Line: Osteosarcoma (OS) cells
Concentration: 10 μM, 20 μM
Incubation Time: 24 h
Result: Repressed both the mRNA and protein level of COX-2 in OS cells in a dose-dependent fashion.
In Vivo

Euxanthone (40-80 mg/kg) could significantly decrease the number of metastatic nodules in lung tissue in a pulmonary metastasis model[1].
Euxanthone (30-60 mg/kg; p.o.;once a day; for 7 days) treatment normalized Bnip3, Beclin1, Pink1, Parkin, p53, Bax, caspase-3, and LC3 II/I in bearing bilateral common carotid artery occlusion (BCCAO). Euxanthone modulates mitophagy and apoptosis induces by mitochondrial stress mediated by mitochondrial fragmentation[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Forty male ICR mice (20 g) induced cerebral ischemia and reperfusion[2]
Dosage: 30 mg/kg, 60 mg/kg
Administration: p.o.;once a day; for 7 days
Result: Markedly attenuated BCCAO triggered mitochondrial stress and related breakdown.
Molecular Weight

228.20

Formula

C13H8O4
CAS No.
SMILES

O=C1C2=C(OC3=C1C=C(O)C=C3)C=CC=C2O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Euxanthone Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Euxanthone529-61-3Autophagyoxidative stressxanthoneanti-neoplastic and neuroprotective activitiesCOX-2anti-metastaticInhibitorinhibitorinhibit

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