2. Immunology/Inflammation Apoptosis
  3. CD19 Apoptosis
  4. Obexelimab

Obexelimab  (Synonyms: XmAb5871)

Cat. No.: HY-P99761 Purity: 95.00%
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Obexelimab (XmAb5871) is a humanized anti-CD19 antibody. Obexelimab works by inhibiting B cell receptor (BCR) mediated calcium influx and promoting the phosphorylation of Fc γ receptor IIb (FcγRIIb), which reduces B cell activation and function, leading to B cell apoptosis. Obexelimab can be used in research for rheumatoid arthritis and systemic lupus erythematosus.

For research use only. We do not sell to patients.

CAS No. : 1690307-05-1

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Obexelimab Related Antibodies

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Description

Obexelimab (XmAb5871) is a humanized anti-CD19 antibody. Obexelimab works by inhibiting B cell receptor (BCR) mediated calcium influx and promoting the phosphorylation of Fc γ receptor IIb (FcγRIIb), which reduces B cell activation and function, leading to B cell apoptosis. Obexelimab can be used in research for rheumatoid arthritis and systemic lupus erythematosus[1][2][3].
Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species

Chimeric
In Vitro

Obexelimab can induce the expression levels of apoptosis pathway related genes and promote B cell apoptosis[1].
Obexelimab (10 μg/mL, 3 min) inhibits B cell activation and function by suppressing BCR mediated calcium flux and promoting Fc γ RIIb phosphorylation[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Obexelimab Related Antibodies

Western Blot Analysis[2].

Cell Line: B cells isolated from PBMC of healthy and RA donors
Concentration: 10 μg/mL
Incubation Time: 3 min
Result: Stimulated FcγRIIb phosphorylation in healthy and RA B cells.
In Vivo

Obexelimab (10 mg/kg; twice a week; i.p.) can inhibit the autoimmune response of immune deficient mice implanted with peripheral blood mononuclear cells (PBMCs) from rheumatoid arthritis (RA) patients[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female C.B-17 SCID mice transplanted with PBMCs[2].
Dosage: 10 mg/kg
Administration: Intraperitoneal injection (i.p.); twice a week
Result: Resulted in inhibition of various immune responses in mice, including IgG, IgM, RF, ACPA, and anti-tetanus antibodies.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Obexelimab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Biological Activity
  • Loaded Obexelimab on AHC2 biosensor, can bind CD19 Protein, Human (HEK293, His, HY-P74330) with an affinity constant of 1.556E-09 M as determined in BLI assay.
Purity & Documentation
References
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Obexelimab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Obexelimab1690307-05-1XmAb5871XmAb 5871XmAb-5871CD19ApoptosisAnti-CD19 antibodyBCRFcγRIIbB cellapoptosisrheumatoid arthritissystemic lupus erythematosusInhibitorinhibitorinhibit

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