exo-IWR-1 

exo-IWR-1, an inactive stereoisomer of Endo-IWR-1, is a negative control of IWR-1 (HY-12238). IWR-1 is a tankyrase inhibitor which inhibits Wnt/β-catenin signaling pathway^[1][2].

exo-IWR-1 (10 μM) does not influence the number of 293T cells infected with bunyaviruses^[1].
Exo-IWR-1 had no effect on RVFV MP12-GFP infection when cells were either pretreated or treated 1 hpi^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

409.44

C₂₅H₁₉N₃O₃

1127442-87-8

Solid

Light yellow to green yellow

O=C(N1C(C=C2)=CC=C2C(NC3=CC=CC4=C3N=CC=C4)=O)[C@@]5([H])[C@](C1=O)([H])[C@H]6C[C@@H]5C=C6

Room temperature in continental US; may vary elsewhere.

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

• [1]. Brooke Hamion, et al. Genome-wide RNA Interference Screen Identifies Novel Drug Targets for Rift Valley Fever Virus That Minimi the Potential for Drug Resistance.

  [2]. Brooke Harmon, et al. A Genome-Wide RNA Interference Screen Identifies a Role for Wnt/β-Catenin Signaling during Rift Valley Fever Virus Infection. J Virol. 2016 Jul 27;90(16):7084-7097.  [Content Brief]