2. Epigenetics
  3. Histone Methyltransferase
  4. EZH2-IN-15

EZH2-IN-15 is a EZH2 inhibitor. EZH2-IN-15 has anti-tumor activity, and can be used for research of H3K27me3-dependent tumors.

For research use only. We do not sell to patients.

EZH2-IN-15 Chemical Structure

EZH2-IN-15 Chemical Structure

CAS No. : 2098545-98-1

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1 mg USD 195 In-stock
5 mg USD 440 In-stock
10 mg USD 670 In-stock
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Based on 1 publication(s) in Google Scholar

EZH2-IN-15 Related Antibodies

Top Publications Citing Use of Products

View All Histone Methyltransferase Isoform Specific Products:

View All Isoforms
EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D SETDB1/KMT2G SETD2/KMT3A NSD2/MMSET/WHSC1 SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

EZH2-IN-15 is a EZH2 inhibitor. EZH2-IN-15 has anti-tumor activity, and can be used for research of H3K27me3-dependent tumors[1].

Molecular Weight

548.72

Formula

C32H44N4O4
CAS No.
Appearance

Solid

Color

Off-white to yellow

SMILES

O=C1NC(C)=CC(C)=C1CNC(C2=C3C=C(CN4CCCCC4)OC3=CC(N(C5CCOCC5)CC)=C2CC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (227.80 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8224 mL 9.1121 mL 18.2242 mL
5 mM 0.3645 mL 1.8224 mL 3.6448 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8224 mL 9.1121 mL 18.2242 mL 45.5606 mL
5 mM 0.3645 mL 1.8224 mL 3.6448 mL 9.1121 mL
10 mM 0.1822 mL 0.9112 mL 1.8224 mL 4.5561 mL
15 mM 0.1215 mL 0.6075 mL 1.2149 mL 3.0374 mL
20 mM 0.0911 mL 0.4556 mL 0.9112 mL 2.2780 mL
25 mM 0.0729 mL 0.3645 mL 0.7290 mL 1.8224 mL
30 mM 0.0607 mL 0.3037 mL 0.6075 mL 1.5187 mL
40 mM 0.0456 mL 0.2278 mL 0.4556 mL 1.1390 mL
50 mM 0.0364 mL 0.1822 mL 0.3645 mL 0.9112 mL
60 mM 0.0304 mL 0.1519 mL 0.3037 mL 0.7593 mL
80 mM 0.0228 mL 0.1139 mL 0.2278 mL 0.5695 mL
100 mM 0.0182 mL 0.0911 mL 0.1822 mL 0.4556 mL
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EZH2-IN-15 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EZH2-IN-152098545-98-1Histone Methyltransferaseanti-tumorH3K27me3lymphomascancerInhibitorinhibitorinhibit

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