1. Epigenetics
  2. Histone Methyltransferase
  3. EZH2-IN-16

EZH2-IN-16 (Compound 24) is an inhibitor for histone methyltransferase (EZH2). EZH2-IN-16 inhibits EZH2 and EZH2 Y641F, with IC50 of 37.6 and 79.1 nM. EZH2-IN-16 inhibits proliferation of WSU-DLCL2, with GI50 of 0.2 μM.

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EZH2-IN-16 Chemical Structure

EZH2-IN-16 Chemical Structure

CAS No. : 2238820-26-1

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Description

EZH2-IN-16 (Compound 24) is an inhibitor for histone methyltransferase (EZH2). EZH2-IN-16 inhibits EZH2 and EZH2 Y641F, with IC50 of 37.6 and 79.1 nM. EZH2-IN-16 inhibits proliferation of WSU-DLCL2, with GI50 of 0.2 μM[1].

IC50 & Target

EZH2 WT

37.6 nM (IC50)

EZH2 Y641F mutant type

79.1 nM (IC50)

Molecular Weight

542.67

Formula

C32H38N4O4

CAS No.
SMILES

O=C(C1=CC(C2=CC=C(N3CCOCC3)C=C2)=CC(N(CC)C(C4CC4)=O)=C1C)NCC5=C(C)C=C(C)NC5=O

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Purity & Documentation
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
EZH2-IN-16
Cat. No.:
HY-149463
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