2. Epigenetics
  3. Histone Methyltransferase
  4. EZH2-IN-22

EZH2-IN-22 (example 92) is a potent EZH2 inhibitor with IC50 values of <0.00051, <0.00051, 0.00052 µM for EZH2 (Y641N), EZH2 (Y641F), EZH2 (wt), respectively. EZH2-IN-22 shows antiproliferation activity.

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EZH2-IN-22 Chemical Structure

EZH2-IN-22 Chemical Structure

CAS No. : 2766231-05-2

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EZH2-IN-22 Related Antibodies

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View All Histone Methyltransferase Isoform Specific Products:

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EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D SETDB1/KMT2G SETD2/KMT3A NSD2/MMSET/WHSC1 SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

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Description

EZH2-IN-22 (example 92) is a potent EZH2 inhibitor with IC50 values of <0.00051, <0.00051, 0.00052 µM for EZH2 (Y641N), EZH2 (Y641F), EZH2 (wt), respectively. EZH2-IN-22 shows antiproliferation activity[1].

IC50 & Target[1]

EZH2 Y641N

<0.00051 μM (IC50)

EZH2 Y641F mutant type

<0.00051 μM (IC50)

EZH2 WT

0.00052 μM (IC50)

Molecular Weight

666.80

Formula

C36H50N4O8
CAS No.
SMILES

OC(/C=C\C(O)=O)=O.CCN(C1CCOCC1)C2=C(C(C(NCC3=C(C=C(NC3=O)C)C)=O)=CC(O[C@@H]4C[C@@H](N5CCCCC5)C4)=C2)C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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EZH2-IN-22 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EZH2-IN-222766231-05-2Histone MethyltransferaseWSU-DLCL2 cellsantiproliferationPfeiffer cellsInhibitorinhibitorinhibit

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