2. Membrane Transporter/Ion Channel Metabolic Enzyme/Protease Neuronal Signaling
  3. TRP Channel Endogenous Metabolite
  4. Farnesyl pyrophosphate ammonium

Farnesyl pyrophosphate ammonium  (Synonyms: Farnesyl diphosphate ammonium)

Cat. No.: HY-113037C Purity: ≥95.0%
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Farnesyl pyrophosphate ammonium salt, a 15-carbon isoprenoid, is a metabolic intermediate of the mevalonate (MVA) pathway. Farnesyl pyrophosphate ammonium salt is a TRPM2 (TRP Channel) agonist, and activates TRPM2 opening for ion influx. Farnesyl pyrophosphate ammonium salt is a key branch substrate for cholesterol synthesis, ubiquinones synthesis, protein farnesylation decoration, and geranyl-geranyl pyrophosphate (GGPP) synthesis.

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Farnesyl pyrophosphate ammonium Chemical Structure

Farnesyl pyrophosphate ammonium Chemical Structure

CAS No. : 116057-57-9

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10 mg USD 1680 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Farnesyl pyrophosphate ammonium salt, a 15-carbon isoprenoid, is a metabolic intermediate of the mevalonate (MVA) pathway. Farnesyl pyrophosphate ammonium salt is a TRPM2 (TRP Channel) agonist, and activates TRPM2 opening for ion influx. Farnesyl pyrophosphate ammonium salt is a key branch substrate for cholesterol synthesis, ubiquinones synthesis, protein farnesylation decoration, and geranyl-geranyl pyrophosphate (GGPP) synthesis[1].

Molecular Weight

433.42

Formula

C15H37N3O7P2
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

O=P(O)(O)OP(OC/C=C(C)/CC/C=C(C)/CC/C=C(C)/C)(O)=O.N.N.N
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Solution, -20°C, 2 years
Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (230.72 mM; Need ultrasonic)

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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V2

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Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥97.0%

SDS (393 KB)

COA (244 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.3072 mL 11.5362 mL 23.0723 mL 57.6808 mL
5 mM 0.4614 mL 2.3072 mL 4.6145 mL 11.5362 mL
10 mM 0.2307 mL 1.1536 mL 2.3072 mL 5.7681 mL
15 mM 0.1538 mL 0.7691 mL 1.5382 mL 3.8454 mL
20 mM 0.1154 mL 0.5768 mL 1.1536 mL 2.8840 mL
25 mM 0.0923 mL 0.4614 mL 0.9229 mL 2.3072 mL
30 mM 0.0769 mL 0.3845 mL 0.7691 mL 1.9227 mL
40 mM 0.0577 mL 0.2884 mL 0.5768 mL 1.4420 mL
50 mM 0.0461 mL 0.2307 mL 0.4614 mL 1.1536 mL
60 mM 0.0385 mL 0.1923 mL 0.3845 mL 0.9613 mL
80 mM 0.0288 mL 0.1442 mL 0.2884 mL 0.7210 mL
100 mM 0.0231 mL 0.1154 mL 0.2307 mL 0.5768 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Farnesyl pyrophosphate ammonium Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Farnesyl pyrophosphate116057-57-9Farnesyl diphosphateTRP ChannelEndogenous MetaboliteTransient receptor potential channelsGGPP synthesision influxMVA pathwayInhibitorinhibitorinhibit

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