(E/Z)-Farnesyl pyrophosphate  (Synonyms: (E/Z)-Farnesyl diphosphate)

(E/Z)-Farnesyl pyrophosphate ((E/Z)-Farnesyl diphosphate), a 15-carbon isoprenoid, is a metabolic intermediate of the mevalonate (MVA) pathway. (E/Z)-Farnesyl pyrophosphate is a TRPM2 (TRP Channel) agonist, activates TRPM2 opening for ion influx. (E/Z)-Farnesyl pyrophosphate is a key branch substrate for cholesterol synthesis, ubiquinones synthesis, protein farnesylation decoration, and geranyl-geranyl pyrophosphate (GGPP) synthesis^[1].

(E/Z)-Farnesyl pyrophosphate functions as an identified danger signal to trigger acute cell death leading to neuron loss in stroke. Harboring both a hydrophobic 15-carbon isoprenyl chain and a heavily charged pyrophosphate head, (E/Z)-Farnesyl pyrophosphate leads to acute cell death independent of its downstream metabolic pathways. Mechanistically, extracellular calcium influx and the cation channel transient receptor potential melastatin 2 (TRPM2) exhibit essential roles in (E/Z)-Farnesyl pyrophosphate-induced cell death. (E/Z)-Farnesyl pyrophosphate activates TRPM2 opening for ion influx^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In terms of a mouse model constructing by middle cerebral artery occlusion (MCAO), (E/Z)-Farnesyl pyrophosphate accumulates in the brain, which indicates the function of the (E/Z)-Farnesyl pyrophosphate and TRPM2 danger signal axis in ischemic injury. (E/Z)-Farnesyl pyrophosphate/TRPM2 signaling axis and the MVA pathway exhibit important roles in brain ischemia and potentially neurodegenerative diseases^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

382.33

C₁₅H₂₈O₇P₂

13058-04-3

O=P(O)(OP(O)(O)=O)OC/C=C(C)/CC/C=C(C)/CC/C=C(C)/C

Room temperature in continental US; may vary elsewhere.

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• [1]. Jing Chen, et al. Farnesyl pyrophosphate is a new danger signal inducing acute cell death. PLoS Biol. 2021 Apr 26;19(4):e3001134.  [Content Brief]